Randomized Trial of Early Bubble Continuous Positive Airway Pressure for Very Low Birth Weight Infants

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dc.contributor.authorTapia, Jose L.
dc.contributor.authorUrzua, Soledad
dc.contributor.authorBancalari, Aldo
dc.contributor.authorMeritano, Javier
dc.contributor.authorTorres, Gabriela
dc.contributor.authorFabres, Jorge
dc.contributor.authorToro, Claudia A.
dc.contributor.authorRivera, Fabiola
dc.contributor.authorCespedes, Elizabeth
dc.contributor.authorBurgos, Jaime F.
dc.contributor.authorMariani, Gonzalo
dc.contributor.authorRoldan, Liliana
dc.contributor.authorSilvera, Fernando
dc.contributor.authorGonzalez, Agustina
dc.contributor.authorDominguez, Angelica
dc.contributor.authorS Amer Neocosur Network
dc.date.accessioned2024-01-10T12:07:56Z
dc.date.available2024-01-10T12:07:56Z
dc.date.issued2012
dc.description.abstractObjective To determine whether very low birth weight infants (VLBWIs), initially supported with continuous positive airway pressure (CPAP) and then selectively treated with the INSURE (intubation, surfactant, and extubation to CPAP; CPAP/INSURE) protocol, need less mechanical ventilation than those supported with supplemental oxygen, surfactant, and mechanical ventilation if required (Oxygen/mechanical ventilation [MV]).
dc.description.abstractStudy design In a multicenter randomized controlled trial, spontaneously breathing VLBWIs weighing 800-1500 g were allocated to receive either therapy. In the CPAP/INSURE group, if respiratory distress syndrome (RDS) did not occur, CPAP was discontinued after 3-6 hours. If RDS developed and the fraction of inspired oxygen (FiO(2)) was >0.35, the INSURE protocol was indicated. Failure criteria included FiO(2) >0.60, severe apnea or respiratory acidosis, and receipt of more than 2 doses of surfactant. In the Oxygen/MV group, in the presence of RDS, supplemental oxygen without CPAP was given, and if FiO(2) was >0.35, surfactant and mechanical ventilation were provided.
dc.description.abstractResults A total of 256 patients were randomized to either the CPAP/INSURE group (n = 131) or the Oxygen/MV group (n = 125). The need for mechanical ventilation was lower in the CPAP/INSURE group (29.8% vs 50.4%; P = .001), as was the use of surfactant (27.5% vs 46.4%; P = .002). There were no differences in death, pneumothorax, bronchopulmonary dysplasia, and other complications of prematurity between the 2 groups.
dc.description.abstractConclusion CPAP and early selective INSURE reduced the need for mechanical ventilation and surfactant in VLBWIs without increasing morbidity and death. These results may be particularly relevant for resource-limited regions. (J Pediatr 2012;square:square-square).
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jpeds.2011.12.054
dc.identifier.eissn1097-6833
dc.identifier.issn0022-3476
dc.identifier.pubmedidMEDLINE:22402568
dc.identifier.urihttps://doi.org/10.1016/j.jpeds.2011.12.054
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76340
dc.identifier.wosidWOS:000305753700018
dc.information.autorucMedicina;Dominguez A ;S/I;131798
dc.information.autorucMedicina;Fabres J ;S/I;71713
dc.information.autorucMedicina;Tapia J;S/I;99000
dc.information.autorucMedicina;Toro C;S/I;129212
dc.information.autorucMedicina;Urzua S;S/I;135691
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherMOSBY-ELSEVIER
dc.revistaJOURNAL OF PEDIATRICS
dc.rightsacceso restringido
dc.subjectRESPIRATORY-DISTRESS-SYNDROME
dc.subjectPREMATURE-INFANTS
dc.subjectSURFACTANT THERAPY
dc.subjectNASAL CPAP
dc.subjectNEWBORNS
dc.subjectOUTCOMES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRandomized Trial of Early Bubble Continuous Positive Airway Pressure for Very Low Birth Weight Infants
dc.typeartículo
dc.volumen161
sipa.codpersvinculados131798
sipa.codpersvinculados71713
sipa.codpersvinculados99000
sipa.codpersvinculados129212
sipa.codpersvinculados135691
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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