Bile acids increase response and expression of human myometrial oxytocin receptor

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dc.contributor.authorGermain, AM
dc.contributor.authorKato, S
dc.contributor.authorCarvajal, JA
dc.contributor.authorValenzuela, GJ
dc.contributor.authorValdes, GL
dc.contributor.authorGlasinovic, JC
dc.date.accessioned2024-01-10T13:11:27Z
dc.date.available2024-01-10T13:11:27Z
dc.date.issued2003
dc.description.abstractOBJECTIVE: We tested the hypothesis that during intrahepatic cholestasis of pregnancy bile acids activate the myometrial oxytocin receptor pathway.
dc.description.abstractSTUDY DESIGN: Myometrial sensitivity to oxytocin and oxytocin-receptor messenger RNA and protein level was investigated. The ability of cholic acid to mediate such changes was evaluated.
dc.description.abstractRESULTS: Cholestasis patients required lesser oxytocin to elicit four uterine contractions in 10 minutes (1.3 0.6 vs 3.6 0.8 J, P < .05, n = 7) and had lower in vitro ED50 (1.6 x 10-10 mol/L vs 1.0 x 10-8 mol/L, P < .05, n = 7) than controls. The 24-hour incubation of control myometrial strips (n = 7) with cholic acid (20 mmol/L) increased oxytocin sensitivity. Incubation of cultured myometrial cells (n = 5) with cholic acid increased oxytocin-receptor expression (messenger RNA and protein).
dc.description.abstractCONCLUSION: We demonstrate that during intrahepatic cholestasis of pregnancy, an activation of the oxytocin receptor pathway occurs. This event seems to be the result of a cholic acid-mediated increase in oxytocin-receptor expression.
dc.fechaingreso.objetodigital2024-05-06
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1067/S0002-9378(03)00545-3
dc.identifier.issn0002-9378
dc.identifier.pubmedidMEDLINE:14520238
dc.identifier.urihttps://doi.org/10.1067/S0002-9378(03)00545-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78048
dc.identifier.wosidWOS:000185219100060
dc.information.autorucMedicina;Carvajal J;S/I;3345
dc.information.autorucMedicina;Valdés G;S/I;98654
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final582
dc.pagina.inicio577
dc.publisherMOSBY, INC
dc.revistaAMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
dc.rightsacceso restringido
dc.subjectintrahepatic cholestasis of pregnancy
dc.subjectoxytocin receptor
dc.subjectINTRA-HEPATIC CHOLESTASIS
dc.subjectINTRAHEPATIC CHOLESTASIS
dc.subjectOBSTETRIC CHOLESTASIS
dc.subjectUTERINE ACTIVITY
dc.subjectPREGNANT-WOMEN
dc.subjectMESSENGER-RNA
dc.subjectCHOLIC-ACID
dc.subjectDECIDUA
dc.subjectPROTEIN
dc.subjectCELLS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBile acids increase response and expression of human myometrial oxytocin receptor
dc.typeartículo
dc.volumen189
sipa.codpersvinculados3345
sipa.codpersvinculados98654
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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