Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses

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dc.contributor.authorVarela Nallar, Lorena
dc.contributor.authorAlfaro, Ivan E.
dc.contributor.authorSerrano, Felipe G.
dc.contributor.authorParodi, Jorge
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2024-01-10T14:22:28Z
dc.date.available2024-01-10T14:22:28Z
dc.date.issued2010
dc.description.abstractGrowing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the maturation of the central nervous system. We report here that Wingless-type family member 5A (Wnt-5a) is expressed early in development and stimulates dendrite spine morphogenesis, inducing de novo formation of spines and increasing the size of the preexisting ones in hippocampal neurons. Wnt-5a increased intracellular calcium concentration in dendritic processes and the amplitude of NMDA spontaneous miniature currents. Acute application of Wnt-5a increased the amplitude of field excitatory postsynaptic potentials (fEPSP) in hippocampal slices, an effect that was prevented by calcium-channel blockers. The physiological relevance of our findings is supported by studies showing that Wnt scavengers decreased spine density, miniature excitatory postsynaptic currents, and fEPSP amplitude. We conclude that Wnt-5a stimulates different aspects of synaptic differentiation and plasticity in the mammalian central nervous system.
dc.description.funderBasal Center for Excellence in Science and Technology
dc.description.funderComision Nacional de Investigacion Cientifica y Tecnologica
dc.fechaingreso.objetodigital2024-04-25
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1073/pnas.1010011107
dc.identifier.issn0027-8424
dc.identifier.pubmedidMEDLINE:21084636
dc.identifier.urihttps://doi.org/10.1073/pnas.1010011107
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79942
dc.identifier.wosidWOS:000285050800058
dc.information.autorucCiencias Biológicas;Alfaro I;S/I;158179
dc.information.autorucCiencias Biológicas;Inestrosa N;S/I;99331
dc.information.autorucCiencias Biológicas;Parodi J ;S/I;202573
dc.information.autorucCiencias Biológicas;Serrano F;S/I;156061
dc.information.autorucCiencias Biológicas;Varela-Nallar L;S/I;127946
dc.issue.numero49
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final21169
dc.pagina.inicio21164
dc.publisherNATL ACAD SCIENCES
dc.revistaPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
dc.rightsacceso abierto
dc.subjectHIPPOCAMPAL-NEURONS
dc.subjectAXON GUIDANCE
dc.subjectRECEPTORS
dc.subjectTRANSMISSION
dc.subjectPROTEINS
dc.subjectPATHWAYS
dc.subjectCALCIUM
dc.subjectRELEASE
dc.subjectBINDING
dc.subjectCELLS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
dc.typeartículo
dc.volumen107
sipa.codpersvinculados158179
sipa.codpersvinculados99331
sipa.codpersvinculados202573
sipa.codpersvinculados156061
sipa.codpersvinculados127946
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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