How far are we from predicting multi-drug interactions during treatment for COVID-19 infection?

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dc.contributor.authorLozano, Benjamin
dc.contributor.authorSantibanez, Javier
dc.contributor.authorSeverino, Nicolas
dc.contributor.authorSaldias, Cristina
dc.contributor.authorVera, Magdalena
dc.contributor.authorRetamal, Jaime
dc.contributor.authorTorres, Soledad
dc.contributor.authorBarrera, Nelson P.
dc.date.accessioned2024-01-10T12:37:12Z
dc.date.available2024-01-10T12:37:12Z
dc.date.issued2022
dc.description.abstractSeriously ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and hospitalized in intensive care units (ICUs) are commonly given a combination of drugs, a process known as multi-drug treatment. After extracting data on drug-drug interactions with clinical relevance from available online platforms, we hypothesize that an overall interaction map can be generated for all drugs administered. Furthermore, by combining this approach with simulations of cellular biochemical pathways, we may be able to explain the general clinical outcome. Finally, we postulate that by applying this strategy retrospectively to a cohort of patients hospitalized in ICU, a prediction of the timing of developing acute kidney injury (AKI) could be made. Whether or not this approach can be extended to other diseases is uncertain. Still, we believe it represents a valuable pharmacological insight to help improve clinical outcomes for severely ill patients.
dc.fechaingreso.objetodigital2024-05-28
dc.fuente.origenWOS
dc.identifier.doi10.1111/bph.15819
dc.identifier.eissn1476-5381
dc.identifier.issn0007-1188
dc.identifier.urihttps://doi.org/10.1111/bph.15819
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76784
dc.identifier.wosidWOS:000773677500001
dc.information.autorucFacultad de Medicina; Vera Alarcon, Maria Magdalena; S/I; 226652
dc.issue.numero14
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final3838
dc.pagina.inicio3831
dc.publisherWILEY
dc.rightsacceso restringido
dc.subjectacute kidney injury
dc.subjectbiochemical simulations
dc.subjectCOVID-19 treatment
dc.subjectdrug-drug interaction
dc.subjectintensive care unit
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHow far are we from predicting multi-drug interactions during treatment for COVID-19 infection?
dc.typeartículo
dc.volumen179
sipa.codpersvinculados226652
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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