HIV GP120 protein increases the function of connexin 43 hemichannels and pannexin-1 channels in astrocytes: Repercussions on astroglial function

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dc.catalogadorjlo
dc.contributor.authorGajardo Gómez, Rosario
dc.contributor.authorSantibáñez, Cristian A.
dc.contributor.authorLabra Ramírez, Valeria Cristina
dc.contributor.authorGómez, Gonzalo I.
dc.contributor.authorEugenin, Eliseo A.
dc.contributor.authorOrellana Roca, Juan Andrés
dc.date.accessioned2024-10-14T19:31:38Z
dc.date.available2024-10-14T19:31:38Z
dc.date.issued2020
dc.description.abstractAt least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively known as HIV-associated neurocognitive disorders (HAND). The molecular mechanisms that amplify damage within the brain of HIV-infected individuals are unknown. Recently, we described that HIV augments the opening of connexin-43 (Cx43) hemichannels in cultured human astrocytes, which result in the collapse of neuronal processes. Whether HIV soluble viral proteins such as gp120, can regulate hemichannel opening in astrocytes is still ignored. These channels communicate the cytosol with the extracellular space during pathological conditions. We found that gp120 enhances the function of both Cx43 hemichannels and pannexin-1 channels in mouse cortical astrocytes. These effects depended on the activation of IL-1 beta/TNF-alpha, p38 MAP kinase, iNOS, cytoplasmic Ca2+ and purinergic signaling. The gp120-induced channel opening resulted in alterations in Ca2+ dynamics, nitric oxide production and ATP release. Although the channel opening evoked by gp120 in astrocytes was reproduced in ex vivo brain preparations, these responses were heterogeneous depending on the CA1 region analyzed. We speculate that soluble gp120-induced activation of astroglial Cx43 hemichannels and pannexin-1 channels could be crucial for the pathogenesis of HAND.
dc.fechaingreso.objetodigital2024-10-14
dc.format.extent23 páginas
dc.fuente.origenConveris
dc.identifier.converisid1
dc.identifier.doi10.3390/ijms21072503
dc.identifier.issn1422-0067
dc.identifier.pubmedidMEDLINE:32260308
dc.identifier.scopusid2-s2.0-85083022818
dc.identifier.urihttps://doi.org/10.3390/ijms21072503
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88204
dc.identifier.wosidWOS:000535574200245
dc.information.autorucEscuela de Medicina; Gajardo Gómez, Rosario; S/I; 205479
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Labra Ramírez, Valeria Cristina; S/I; 1145786
dc.information.autorucEscuela de Medicina; Orellana Roca, Juan Andrés; 0000-0003-4076-207X; 126007
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final23
dc.pagina.inicio1
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.subjectHemichannels
dc.subjectConnexins
dc.subjectGp120
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleHIV GP120 protein increases the function of connexin 43 hemichannels and pannexin-1 channels in astrocytes: Repercussions on astroglial function
dc.typeartículo
dc.volumen21
sipa.codpersvinculados205479
sipa.codpersvinculados1145786
sipa.codpersvinculados126007
sipa.trazabilidadConveris;20-07-2021
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