Interleukin-19 in fetal systemic inflammation

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dc.contributor.authorSavasan, Zeynep Alpay
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorRomero, Roberto
dc.contributor.authorHussein, Youssef
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorXu, Yi
dc.contributor.authorDong, Zhong
dc.contributor.authorKim, Chong Jai
dc.contributor.authorHassan, Sonia S.
dc.date.accessioned2024-01-10T13:14:01Z
dc.date.available2024-01-10T13:14:01Z
dc.date.issued2012
dc.description.abstractObjective: The fetal inflammatory response syndrome (FIRS) is considered the fetal counterpart of the systemic inflammatory response syndrome (SIRS), which can be caused by infection and non-infection-related insults. Although the initial response is mediated by pro-inflammatory signals, the control of this response is achieved by anti-inflammatory mediators which are essential for the successful outcome of the affected individual. Interleukin (IL)-19 is capable of stimulating the production of IL-10, a major anti-inflammatory cytokine, and is a potent inducer of the T-helper 2 (Th2) response. The aim of this study was to determine if there is a change in umbilical cord plasma IL-19 and IL-10 concentrations in preterm neonates with and without acute funisitis, the histologic counterpart of FIRS. Methods: A case-control study was conducted including 80 preterm neonates born after spontaneous labor. Neonates were classified according to the presence (n = 40) or absence of funisitis (n = 40), which is the pathologic hallmark of FIRS. Neonates in each group were also matched for gestational age. Umbilical cord plasma IL-19 and IL-10 concentrations were determined by ELISA. Results: 1) The median umbilical cord plasma IL-19 concentration was 2.5-fold higher in neonates with funisitis than in those without funisitis (median 87 pg/mL; range 20.6-412.6 pg/mL vs. median 37 pg/mL; range 0-101.7 pg/mL; p < 0.001); 2) newborns with funisitis had a significantly higher median umbilical cord plasma IL-10 concentration than those without funisitis (median 4 pg/mL; range 0-33.5 pg/mL vs. median 2 pg/mL; range 0-13.8 pg/mL; p < 0.001); and 3) the results were similar when we included only patients with funisitis who met the definition of FIRS by umbilical cord plasma IL-6 concentrations >= 17.5 pg/mL (p < 0.001). Conclusion: IL-19 and IL-10 are parts of the immunologic response of FIRS. A subset of fetuses with FIRS had high umbilical cord plasma IL-19 concentrations. In utero exposure to high systemic concentrations of IL-19 may reprogram the immune response.
dc.description.funderPerinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/14767058.2011.605917
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmedidMEDLINE:21767236
dc.identifier.urihttps://doi.org/10.3109/14767058.2011.605917
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78365
dc.identifier.wosidWOS:000305704000026
dc.information.autorucMedicina;Kusanovic J;S/I;1008900
dc.issue.numero7
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1005
dc.pagina.inicio995
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsacceso restringido
dc.subjectFetal inflammatory response syndrome (FIRS)
dc.subjectchorioamnionitis
dc.subjectfunisitis
dc.subjectanti-inflammatory limb
dc.subjectIL-10
dc.subjectpreterm repture of membranes (PROM)
dc.subjectchildhood asthma
dc.subjectSIDS
dc.subjectprematurity
dc.subjectpreterm labor
dc.subjectimmune programming
dc.subjectPRETERM PREMATURE RUPTURE
dc.subjectNECROSIS-FACTOR-ALPHA
dc.subjectAMNIOTIC-FLUID INTERLEUKIN-6
dc.subjectWHITE-MATTER LESIONS
dc.subjectEXPERIMENTAL INTRAUTERINE INFECTION
dc.subjectHERPES-SIMPLEX INFECTION
dc.subjectUMBILICAL-CORD PLASMA
dc.subjectINFANT-DEATH-SYNDROME
dc.subjectC-REACTIVE PROTEIN
dc.subjectINTRAAMNIOTIC ENDOTOXIN
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleInterleukin-19 in fetal systemic inflammation
dc.typeartículo
dc.volumen25
sipa.codpersvinculados1008900
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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