Impact of pomegranate peel extract on gut microbiota composition and metabolic health parameters in high-fat diet-fed mice

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dc.article.number104663
dc.catalogadorgrr
dc.contributor.authorDuarte, Lissette
dc.contributor.authorBustamante, Andrés
dc.contributor.authorOrellana, Juan Francisco
dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorMagne, Fabien
dc.contributor.authorFuentes, Jocelyn
dc.contributor.authorSpeisky, Hernán
dc.contributor.authorEcheverria Gonzalez, Francisca Cecilia
dc.date.accessioned2024-07-18T14:45:43Z
dc.date.available2024-07-18T14:45:43Z
dc.date.issued2024
dc.description.abstractBackground: Gut microbiota (GM) plays a crucial role in obesity pathophysiology and is heavily influenced by dietary factors. Polyphenols have shown a positive effect in preventing and treating obesity, which is blunted in the absence of GM. Pomegranate peel, known for its high content of polyphenols (ellagitannins), has been found to exhibit favorable metabolic effects in obesity. Interestingly, ellagitannins are metabolized by the action of GM. However, the specific impact of pomegranate peel extract (PPE) on GM and metabolism remains unclear.Objective: to evaluate the effect of a PPE (microencapsulated or not) on the composition of GM in high-fat diet (HFD)-fed mice and analyze its association with metabolic parameters.Methods: Male C57BL/6J mice (n = 40) were randomly distributed into five groups: control diet (CD), HFD, HFD + inulin (IN), HFD + PPE (50 mg/kg/d of total polyphenols; TP), and HFD + MPPE (50 mg/kg/d TP), for 14 weeks. Liver and serum antioxidant status were assessed. GM composition, further relative abundances, and biodiversity were calculated from cecal content samples. The bacterial community clustering was analyzed using a canonical-correlation analysis (CCA). GM parameters and metabolic outcomes were evaluated for correlation (Spearman’s correlation), p < 0.05.Results: PPE and MPPE showed increased energy expenditure, reduced liver arachidonic acid content, elevated antioxidant capacity, and higher GM alpha diversity compared to HFD alone.Conclusion: PPE, regardless of encapsulation, ameliorated metabolic alterations induced by HFD, potentially through modulation of GM. These findings provide data on the therapeutic potential of PPE in managing obesityrelated metabolic dysfunction.
dc.fechaingreso.objetodigital2024-09-05
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.fbio.2024.104663
dc.identifier.issn2212-4292
dc.identifier.scopusidSCOPUS_ID:2-s2.0-85197295626
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2024.104663
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87107
dc.information.autorucDepartamento de Ciencias de la Salud; Echeverria Gonzalez, Francisca Cecilia; 0000-0002-9661-0377; 1232657
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaFood Bioscience
dc.rightsacceso restringido
dc.rights.licenseAttribution-NonCommercial-NoDerivs (CC BY-NC-ND)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAgroindustrial by-products
dc.subjectEllagitannins
dc.subjectBacterial biodiversity
dc.subjectDiet-induced obesity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImpact of pomegranate peel extract on gut microbiota composition and metabolic health parameters in high-fat diet-fed mice
dc.typeartículo
dc.volumen61
sipa.codpersvinculados1232657
sipa.trazabilidadORCID;2024-07-15
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