A cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)

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dc.contributor.authorIturriaga, Carolina
dc.contributor.authorEiffler, Nat
dc.contributor.authorAniba, Rad
dc.contributor.authorPérez Mateluna, Guillermo
dc.contributor.authorMeyer, Jessica K. V.
dc.contributor.authorSeverino Cuevas, Nicolás Felipe
dc.contributor.authorBorzutzky Schachter, Arturo
dc.contributor.authorPerret Pérez, Cecilia
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorGarcía-Huidobro Munita, Diego Nicolás
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorEiffler, Nat
dc.contributor.authorAniba, Rad
dc.contributor.authorPérez Mateluna, Guillermo
dc.contributor.authorMeyer, Jessica K. V.
dc.contributor.authorSeverino Cuevas, Nicolás Felipe
dc.contributor.authorBorzutzky Schachter, Arturo
dc.contributor.authorPerret Pérez, Cecilia
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorGarcía-Huidobro Munita, Diego Nicolás
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorEiffler, Nat
dc.contributor.authorAniba, Rad
dc.contributor.authorPérez Mateluna, Guillermo
dc.contributor.authorMeyer, Jessica K. V.
dc.contributor.authorSeverino Cuevas, Nicolás Felipe
dc.contributor.authorBorzutzky Schachter, Arturo
dc.contributor.authorPerret Pérez, Cecilia
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorGarcía-Huidobro Munita, Diego Nicolás
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorEiffler, Nat
dc.contributor.authorAniba, Rad
dc.contributor.authorPérez Mateluna, Guillermo
dc.contributor.authorMeyer, Jessica K. V.
dc.contributor.authorSeverino Cuevas, Nicolás Felipe
dc.contributor.authorBorzutzky Schachter, Arturo
dc.contributor.authorPerret Pérez, Cecilia
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorGarcía-Huidobro Munita, Diego Nicolás
dc.date.accessioned2021-08-19T15:07:02Z
dc.date.available2021-08-19T15:07:02Z
dc.date.issued2021
dc.date.updated2021-08-15T00:03:11Z
dc.description.abstractAbstract Background SARS-CoV-2 infection rapidly spreads in populations due to the high rates of community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence of Coronavirus Disease 19 (COVID-19). Herein we provide a protocol for a cluster randomized trial that will examine the effectiveness of treatment with interferon (IFN) ß-1a compared to standard of care in limiting the transmission of SARS-CoV-2. Co-primary objectives are to determine whether IFN therapy reduces (a) the proportion of infected cases shedding SARS-CoV-2 at day 11 post randomization and (b) the incidence of transmission of SARS-CoV-2 infection from index cases to treatment-eligible household post-exposure contacts at day 11 after randomization. Secondary objectives include assessing the impact of IFN treatment on duration of viral clearance, hospitalizations and fatalities, and evaluating the safety of IFN treatment. Methods Three hundred and ten households, each including an index case with a recent COVID-19 diagnosis and at least one asymptomatic treatment-eligible household contact, will be randomized to receive 3 doses of 125 μg IFN ß-1a by subcutaneous administration (days 1, 6, and 11), or standard of care. All participants will be followed until day 29. Discussion The results from this trial will identify whether IFN ß treatment of mild or moderate COVID-19 cases accelerates viral clearance and prevents disease progression and whether IFN ß treatment of post-exposure contacts of COVID-19 cases reduces transmission of infection. Trial Registration: This trial is registered at ClinicalTrials.gov NCT04552379; date of registration September 17, 2020.
dc.format.extent11 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationBMC Infectious Diseases. 2021 Aug 13;21(1):814
dc.identifier.doi10.1186/s12879-021-06519-4
dc.identifier.urihttps://doi.org/10.1186/s12879-021-06519-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/61941
dc.information.autorucEscuela de Medicina ; Iturriaga, Carolina ; S/I ; 1058623
dc.information.autorucEscuela de Medicina ; Pérez Mateluna, Guillermo ; S/I ; S/I
dc.information.autorucEscuela de Medicina ; Meyer, Jessica K. V. ; S/I ; S/I
dc.information.autorucEscuela de Medicina ; Severino Cuevas, Nicolás Felipe ; S/I ; 149398
dc.information.autorucEscuela de Medicina ; Borzutzky Schachter, Arturo ; 0000-0002-7904-262X ; 5897
dc.information.autorucEscuela de Medicina ; Perret Pérez, Cecilia ; S/I ; 80387
dc.information.autorucEscuela de Medicina ; Castro Rodríguez, José A. ; 0000-0002-0708-4281 ; 113247
dc.information.autorucEscuela de Medicina ; García-Huidobro Munita, Diego Nicolás ; 0000-0003-1964-7640 ; 16671
dc.issue.numeroNo. 814
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaBMC Infectious Diseaseses_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectCOVIDes_ES
dc.subjectCOVID-19es_ES
dc.subjectCoronaviruses_ES
dc.subjectInterferones_ES
dc.subjectProtocoles_ES
dc.subjectTransmissiones_ES
dc.subjectPreventiones_ES
dc.subject.ddc616.2414
dc.subject.deweyMedicina y saludes_ES
dc.titleA cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)es_ES
dc.typeartículo
dc.volumenVol. 21
sipa.codpersvinculados1058623
sipa.codpersvinculados149398
sipa.codpersvinculados5897
sipa.codpersvinculados80387
sipa.codpersvinculados113247
sipa.codpersvinculados16671
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