Attenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice

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dc.contributor.authorContreras-Duarte, Susana
dc.contributor.authorChen, P.
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.contributor.authorUribe Arancibia, Sergio A.
dc.contributor.authorIrarrázaval Mena, Pablo
dc.contributor.authorKopp, S.
dc.contributor.authorKern, S.
dc.contributor.authorMarsche, G.
dc.contributor.authorBusso, Dolores
dc.contributor.authorRigotti Rivera, Attilio
dc.date.accessioned2019-10-17T15:06:00Z
dc.date.available2019-10-17T15:06:00Z
dc.date.issued2018
dc.date.updated2019-10-14T19:12:17Z
dc.description.abstractAbstract Background and aims Atherosclerotic cardiovascular disease is highly prevalent and its underlying pathogenesis involves dyslipidemia including pro-atherogenic high density lipoprotein (HDL) remodeling. Vitamins C and E have been proposed as atheroprotective agents for cardiovascular disease management. However, their effects and benefits on high density lipoprotein function and remodeling are unknown. In this study, we evaluated the role of vitamin C and E on non HDL lipoproteins as well as HDL function and remodeling, along with their effects on inflammation/oxidation biomarkers and atherosclerosis in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. Methods and results: Mice were pre-treated for 5 weeks before and during atherogenic diet feeding with vitamin C and E added to water and diet, respectively. Compared to a control group, combined vitamin C and E administration reduced serum total cholesterol and triglyceride levels by decreasing apo B-48-containing lipoproteins, remodeled HDL particles by reducing phospholipid as well as increasing PON1 and apo D content, and diminished PLTP activity and levels. Vitamin supplementation improved HDL antioxidant function and lowered serum TNF-α levels. Vitamin C and E combination attenuated atherogenesis and increased lifespan in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice. Conclusions Vitamin C and E administration showed significant lipid metabolism regulating effects, including HDL remodeling and decreased levels of apoB-containing lipoproteins, in mice. In addition, this vitamin supplementation generated a cardioprotective effect in a murine model of severe and lethal atherosclerotic ischemic heart disease.
dc.fuente.origenBiomed Central
dc.identifier.citationBiological Research. 2018 Sep 15;51(1):34
dc.identifier.doi10.1186/s40659-018-0183-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26747
dc.issue.numeroNo. 34
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaBiological Researches_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherEnfermedades cardiovasculareses_ES
dc.subject.otherEnfermedades cardiovasculares - Terapiaes_ES
dc.subject.otherVitamina C - Uso terapéuticoes_ES
dc.subject.otherVitamina E - Uso terapéuticoes_ES
dc.titleAttenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in micees_ES
dc.typeartículo
dc.volumenVol. 51
sipa.codpersvinculados90691
sipa.codpersvinculados16572
sipa.codpersvinculados57376
sipa.codpersvinculados161700
sipa.codpersvinculados68489
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