Immunity y Helicobacter pylori
Loading...
Date
2011
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Helicobacter pylori a Gram negative bacterium that colonizes gastric mucosa and that has been associated to different disease such as chronic gastritis, duodenal ulcers and gastric cancer. Although the infection by itself is able to produce damage to the gastric mucosa through the expression and interaction of well-known virulence factors, the immune local response is strongly involved in the pathogenesis of H. pylori-associated diseases. The classic dichotomy T helper type 1 vs type 2 response to explain the damage associated to the bacterium, has been reevaluated in a more complex scenario with the recent description of the T regulatory response and the new patterns of T helper response such as Th17. The extremely well balanced equilibrium between virulence and immune infl ammatory response is mainly regulated by the intensity of the T regulatory response; its suppression would allow the expression of different T helper responses that account for the fi nal damage and clinical outcomes.
Description
Keywords
Helicobacter pylori, regulatory T-cells, T-helper response