The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease

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dc.catalogadordfo
dc.contributor.authorBachmann Barron, María Consuelo
dc.contributor.authorBellalta Bremer, Sofia Paz
dc.contributor.authorBasoalto Escobar, Roque Ignacio
dc.contributor.authorGómez Valenzuela, Fernán Daniel
dc.contributor.authorJalil Contreras, Yorschua Frederick
dc.contributor.authorLepez Rivera, Macarena Paz
dc.contributor.authorMatamoros, José Anibal
dc.contributor.authorVon Bernhardi Montgomery, Rommy Edth B.
dc.date.accessioned2024-10-23T15:01:49Z
dc.date.available2024-10-23T15:01:49Z
dc.date.issued2020
dc.description.abstractThe aging process is driven by multiple mechanisms that lead to changes in energy production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality and increased disease susceptibility. Most aged individuals develop chronic low-grade inflammation, which is an important risk factor for morbidity, physical and cognitive impairment, frailty, and death. At any age, chronic inflammatory diseases are major causes of morbimortality, affecting up to 5-8% of the population of industrialized countries. Several environmental factors can play an important role for modifying the inflammatory state. Genetics accounts for only a small fraction of chronic-inflammatory diseases, whereas environmental factors appear to participate, either with a causative or a promotional role in 50% to 75% of patients. Several of those changes depend on epigenetic changes that will further modify the individual response to additional stimuli. The interaction between inflammation and the environment offers important insights on aging and health. These conditions, often depending on the individual's sex, appear to lead to decreased longevity and physical and cognitive decline. In addition to biological factors, the environment is also involved in the generation of psychological and social context leading to stress. Poor psychological environments and other sources of stress also result in increased inflammation. However, the mechanisms underlying the role of environmental and psychosocial factors and nutrition on the regulation of inflammation, and how the response elicited for those factors interact among them, are poorly understood. Whereas certain deleterious environmental factors result in the generation of oxidative stress driven by an increased production of reactive oxygen and nitrogen species, endoplasmic reticulum stress, and inflammation, other factors, including nutrition (polyunsaturated fatty acids) and behavioral factors (exercise) confer protection against inflammation, oxidative and endoplasmic reticulum stress, and thus ameliorate their deleterious effect. Here, we discuss processes and mechanisms of inflammation associated with environmental factors and behavior, their links to sex and gender, and their overall impact on aging.
dc.fechaingreso.objetodigital2024-10-23
dc.format.extent19 páginas
dc.fuente.origenConveris
dc.identifier.doi10.3389/fimmu.2020.570083
dc.identifier.eissn1664-3224
dc.identifier.pubmedid33162985
dc.identifier.urihttps://doi.org/10.3389/fimmu.2020.570083
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88336
dc.identifier.wosidWOS:000584388200001
dc.information.autorucDepartamento de Ciencias de la Salud; Bachmann Barron Maria Consuelo; 0000-0002-2006-0591; 215825
dc.information.autorucEscuela de Medicina; Bellalta Bremer Sofia Paz; S/I; 1092183
dc.information.autorucEscuela de Medicina; Basoalto Escobar Roque Ignacio; 0000-0002-8908-7397; 1010703
dc.information.autorucEscuela de Medicina; Gomez Valenzuela Fernan Daniel; S/I; 1056425
dc.information.autorucDepartamento de Ciencias de la Salud; Jalil Contreras Yorschua Frederick; 0000-0002-4993-7158; 1079709
dc.information.autorucEscuela de Medicina; Lepez Rivera Macarena Paz; S/I; 1086262
dc.information.autorucEscuela de Medicina; Matamoros Jose Anibal; S/I; 1092793
dc.information.autorucEscuela de Medicina; Von Bernhardi Montgomery Rommy Edth B.; S/I; 62523
dc.language.isoen
dc.nota.accesoacceso abierto
dc.pagina.final19
dc.pagina.inicio1
dc.revistaFrontiers in immunology
dc.rightsacceso abierto
dc.subjectPollution
dc.subjectOxidative stress
dc.subjectNutrition
dc.subjectImmune system
dc.subjectGender
dc.subjectExcercise
dc.subjectEpigenetic changes
dc.subjectDrug abuse
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease
dc.typeartículo de revisión
dc.volumen11
sipa.codpersvinculados215825
sipa.codpersvinculados1092183
sipa.codpersvinculados1010703
sipa.codpersvinculados1056425
sipa.codpersvinculados1079709
sipa.codpersvinculados1086262
sipa.codpersvinculados1092793
sipa.codpersvinculados62523
sipa.trazabilidadConveris;20-07-2021
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