Moxifloxacin vs amoxicillin/clavulanate in the treatment of acute sinusitis

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dc.contributor.authorArrieta, Jose R.
dc.contributor.authorGalgano, Alejandro S.
dc.contributor.authorSakano, Eulalia
dc.contributor.authorFonseca, Ximena
dc.contributor.authorAmabile Cuevas, Carlos F.
dc.contributor.authorHernandez Oliva, Gerardo
dc.contributor.authorVivar, Raul
dc.contributor.authorGonzalez, Gerardo
dc.contributor.authorTorres, Arturo
dc.contributor.authorMASS Latin Am Study Grp
dc.date.accessioned2024-01-10T12:40:39Z
dc.date.available2024-01-10T12:40:39Z
dc.date.issued2007
dc.description.abstractPurpose: The aim of this study was to compare the efficacy and safety of moxifloxacin with that of amoxicillin/clavulanate for the treatment of acute bacterial sinusitis in adults.
dc.description.abstractMaterials and methods: Five hundred seventy-five patients from Latin American countries were randomized to receive oral moxifloxacin 400 mg once daily for 7 days, or oral amoxicillin/ clavulanate 500/125 mg 3 times daily for 10 days, in a prospective, open study.
dc.description.abstractResults: At the test-of-cure visit (7-14 days after the end of therapy), the clinical success rate in the moxifloxacin group was 93.4% similar to that in the amoxicillin/clavulanate group (92.7%). Documented bacteriological eradication plus presumed eradication rates in the moxifloxacin (96.5%) and the amoxicillin/clavulanate (96.7%) groups were also similar. Drug-related adverse events were recorded in 32.2% of patients in the moxifloxacin group and 29.7% in the amoxicillin/clavulanate group. Patient discontinuation in the trial due to adverse events occurred for 10 patients in the moxifloxacin group and 6 in the amoxicillin/clavulanate group.
dc.description.abstractConclusions: Overall, in terms of clinical and bacteriological response, moxifloxacin was equivalent to amoxicillin/clavulanate for the treatment of acute bacterial sinusitis in adults. (C) 2007 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital2024-03-19
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.amjoto.2006.06.016
dc.identifier.eissn1532-818X
dc.identifier.issn0196-0709
dc.identifier.pubmedidMEDLINE:17362810
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2006.06.016
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77334
dc.identifier.wosidWOS:000245162500002
dc.information.autorucMedicina;Fonseca X;S/I;98755
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final82
dc.pagina.inicio78
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaAMERICAN JOURNAL OF OTOLARYNGOLOGY
dc.rightsacceso restringido
dc.subjectACUTE MAXILLARY SINUSITIS
dc.subjectCEFUROXIME AXETIL
dc.subjectADULTS
dc.subjectTISSUE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMoxifloxacin vs amoxicillin/clavulanate in the treatment of acute sinusitis
dc.typeartículo
dc.volumen28
sipa.codpersvinculados98755
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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