Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections

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dc.catalogadordfo
dc.contributor.authorBertrand N., Pablo
dc.contributor.authorVazquez, Yaneisi
dc.contributor.authorBeckhaus, Andrea A.
dc.contributor.authorGonzález Carreño, Liliana Andrea
dc.contributor.authorContreras Sepúlveda, Ana María
dc.contributor.authorFerrés Garrido, Marcela Viviana
dc.contributor.authorPadilla Pérez, Oslando
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2024-01-31T12:39:21Z
dc.date.available2024-01-31T12:39:21Z
dc.description.abstractLower respiratory tract infections (LRTIs) produced by viruses are the most frequent cause of morbidity and mortality in children younger than 5 years of age. The immune response triggered by viral infection can induce a strong inflammation in the airways and cytokines could be considered as biomarkers for disease severity as these molecules modulate the inflammatory response that defines the outcome of patients. Aiming to predict the severity of disease during respiratory tract infections, we conducted a 1-year follow-up observational study in infants who presented upper or lower respiratory tract infections caused by seasonal respiratory viruses. At the time of enrollment, nasopharyngeal swabs (NPS) were obtained from infants to measure mRNA expression and protein levels of IL-3, IL-8, IL-33, and thymic stromal lymphopoietin. While all cytokines significantly increased their protein levels in infants with upper and lower respiratory tract infections as compared to control infants, IL-33 and IL-8 showed a significant increase in respiratory syncytial virus (RSV)-infected patients with LRTI as compared to patients with upper respiratory tract infection. We also found higher viral loads of RSV-positive samples with a greater IL-8 response at the beginning of the symptoms. Data obtained in this study suggest that both IL-8 and IL-33 could be used as biomarkers for clinical severity for infants suffering from LRTIs caused by the RSV.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1093/cei/uxac083
dc.identifier.urihttps://doi.org/10.1093/cei/uxac083
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81086
dc.information.autorucEscuela de Medicina; Bertrand N., Pablo; 0000-0002-7736-0296; 77715
dc.information.autorucFacultad de Ciencias Biológicas; Vázquez, Yaneisi: S/I; 1025308
dc.information.autorucEscuela de Medicina; Beckhaus, Andrea A.; S/I; 142506
dc.information.autorucFacultad de Ciencias Biológicas; González Carreño, Liliana Andrea; S/I; 250114
dc.information.autorucEscuela de Medicina; Contreras Sepúlveda, Ana María; S/I; 149883
dc.information.autorucEscuela de Medicina; Ferrés Garrido, Marcela Viviana; 0000-0001-9415-4657; 66180
dc.information.autorucEscuela de Medicina; Padilla Pérez, Oslando; S/I; 102063
dc.information.autorucKalergis Parra, Alexis Mikes; Escuela de Medicina; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; Bueno, Susan M.; 0000-0002-7551-8088; 113541
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final78
dc.pagina.inicio68
dc.revistaClinical and Experimental Immunology
dc.rightsacceso abierto
dc.subjectCytokines
dc.subjectRespiratory tract infection
dc.subjectRSV
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleIdentification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections
dc.typeartículo
dc.volumen210
sipa.codpersvinculados77715
sipa.codpersvinculados1025308
sipa.codpersvinculados142506
sipa.codpersvinculados250114
sipa.codpersvinculados149883
sipa.codpersvinculados66180
sipa.codpersvinculados102063
sipa.codpersvinculados90610
sipa.codpersvinculados113541
sipa.trazabilidadWOS;2022-10-11
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