A new physiopathological classification of diabetic neuropathy
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
SOC MEDICA SANTIAGO
Abstract
Nowadays, Diabetic Neuropathy (DN) is considered the most common cause of peripheral neuropathy in clinical practice. It can affect sensitive, motor or autonomic nerve fibers, with symmetric, asymmetric, acute or chronic presentations. Due to this variability, with multiple physiopathologic mechanisms involved, a complex clinical classification has been used until recently. The aim of this review is to present a new classification of diabetic neuropathy, based on its physiopathology. It is divided in metabolic microvascular and hypoxic, autoimmune and inflammatory, compressive, secondary to complications of diabetes and related to treatment. It must be understood that DN is not just a functional disease, but a complication of diabetes with molecular and pathological substrates caused by hyperglycemia. Therefore, normalization of blood glucose is a fundamental step towards the successful prevention and treatment of DN. (Rev Med Chile 2012; 140: 1593-1605).
Description
Keywords
Diabetes complications, Diabetic neuropathies, Physiopathology, ADVANCED GLYCATION ENDPRODUCTS, GLUCOSE-METABOLISM, THIAMINE, INSULIN, MANAGEMENT, RELEVANCE, MELLITUS, RECEPTOR, RAGE