3D B1+corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation

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dc.contributor.authorQi, Haikun
dc.contributor.authorLv, Zhenfeng
dc.contributor.authorDiao, Jiameng
dc.contributor.authorTao, Xiaofeng
dc.contributor.authorHu, Junpu
dc.contributor.authorXu, Jian
dc.contributor.authorBotnar, Rene
dc.contributor.authorPrieto, Claudia
dc.contributor.authorHu, Peng
dc.date.accessioned2025-01-20T16:06:33Z
dc.date.available2025-01-20T16:06:33Z
dc.date.issued2024
dc.description.abstractPurposeTo develop a 3D free-breathing cardiac multi-parametric mapping framework that is robust to confounders of respiratory motion, fat, and B1+ inhomogeneities and validate it for joint myocardial T1 and T1 rho mapping at 3T. MethodsAn electrocardiogram-triggered sequence with dual-echo Dixon readout was developed, where nine cardiac cycles were repeatedly acquired with inversion recovery and T1 rho preparation pulses for T1 and T1 rho sensitization. A subject-specific respiratory motion model relating the 1D diaphragmatic navigator to the respiration-induced 3D translational motion of the heart was constructed followed by respiratory motion binning and intra-bin 3D translational and inter-bin non-rigid motion correction. Spin history B1+ inhomogeneities were corrected with optimized dual flip angle strategy. After water-fat separation, the water images were matched to the simulated dictionary for T1 and T1 rho quantification. Phantoms and 10 heathy subjects were imaged to validate the proposed technique. ResultsThe proposed technique achieved strong correlation (T1: R-2 = 0.99; T1 rho: R-2 = 0.98) with the reference measurements in phantoms. 3D cardiac T1 and T1 rho maps with spatial resolution of 2 x 2 x 4 mm were obtained with scan time of 5.4 +/- 0.5 min, demonstrating comparable T1 (1236 +/- 59 ms) and T1 rho (50.2 +/- 2.4 ms) measurements to 2D separate breath-hold mapping techniques. The estimated B1+ maps showed spatial variations across the left ventricle with the septal and inferior regions being 10%-25% lower than the anterior and septal regions. ConclusionThe proposed technique achieved efficient 3D joint myocardial T1 and T1 rho mapping at 3T with respiratory motion correction, spin history B1+ correction and water-fat separation.
dc.description.funderCross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai JiaoTong university School of Medicine
dc.fuente.origenWOS
dc.identifier.doi10.1002/mrm.30317
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.urihttps://doi.org/10.1002/mrm.30317
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89966
dc.identifier.wosidWOS:001329656200001
dc.language.isoen
dc.revistaMagnetic resonance in medicine
dc.rightsacceso restringido
dc.subjectB1+correction
dc.subjectcardiac multi-parametric mapping
dc.subjectfree-breathing
dc.subjectT1 mapping
dc.subjectT1 rho mapping
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title3D B1+corrected simultaneous myocardial T1 and T1ρ mapping with subject-specific respiratory motion correction and water-fat separation
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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