Suspicious Cervical Lymph Nodes Detected after Thyroidectomy for Papillary Thyroid Cancer Usually Remain Stable Over Years in Properly Selected Patients

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dc.contributor.authorRobenshtok, E.
dc.contributor.authorFish, S.
dc.contributor.authorBach, A.
dc.contributor.authorDominguez, Jose M.
dc.contributor.authorShaha, A.
dc.contributor.authorTuttle, R. M.
dc.date.accessioned2024-01-10T14:21:47Z
dc.date.available2024-01-10T14:21:47Z
dc.date.issued2012
dc.description.abstractContext: The risk of loco-regional recurrence in papillary thyroid cancer (PTC) patients ranges from 15-30%. However, the clinical significance of small-volume loco-regional recurrence detected by highly sensitive ultrasonography is unclear.
dc.description.abstractObjective: Our objective was to describe the natural history of abnormal cervical lymph nodes (LN) diagnosed after initial treatment.
dc.description.abstractDesign: We conducted a retrospective cohort study.
dc.description.abstractPatients: 166 PTC with patients who had at least one abnormal LN outside the thyroid be on ultrasound and selected for active surveillance were included.
dc.description.abstractMain Outcome Measure: LN growth during a period of active surveillance was the primary outcome.
dc.description.abstractResults: Most patients had classical PTC (85%) and an intermediate risk of recurrence (77%). The median LN size at the start of the observation period was 1.3 cm (range, 0.5-2.7 cm) in largest diameter, with all nodes having at least one abnormal sonographic characteristic (70% of patients had LN with at least two abnormal features). In almost all patients, the LN were in the lateral neck, primarily in levels 3 (43%) and 4 (58%). After a median follow-up of 3.5 yr, only 20% (33 of 166) grew at least 3 mm, 9% (15 of 166) grew at least 5 mm, and 14% (23 of 166) resolved. None of the clinical or sonographic features were predictive of LN growth (positive predictive value range = 0.21-0.57). There were no local complications (nerve damage or local invasion) related to the abnormal nodes and no disease-related mortality.
dc.description.abstractConclusions: Suspicious cervical LN in the lateral neck usually remain stable for long periods of time in properly selected PTC patients and can be safely followed with serial ultrasounds (J Clin Endocrinol Metab 97: 2706-2713, 2012)
dc.description.funderDavidoff Foundation
dc.description.funderPontificia Universidad Catolica and Becas Chile
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1210/jc.2012-1553
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.pubmedidMEDLINE:22639292
dc.identifier.urihttps://doi.org/10.1210/jc.2012-1553
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79781
dc.identifier.wosidWOS:000307457400054
dc.information.autorucMedicina;Domínguez JM;S/I;9629
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final2713
dc.pagina.inicio2706
dc.publisherENDOCRINE SOC
dc.revistaJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.rightsacceso restringido
dc.subjectTHERAPY
dc.subjectREOPERATION
dc.subjectCARCINOMA
dc.subjectEFFICACY
dc.subjectNODULES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSuspicious Cervical Lymph Nodes Detected after Thyroidectomy for Papillary Thyroid Cancer Usually Remain Stable Over Years in Properly Selected Patients
dc.typeartículo
dc.volumen97
sipa.codpersvinculados9629
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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