Common Carotid Artery Intima-Media Thickness: The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) Study Results

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dc.contributor.authorTouboul, Pierre Jean
dc.contributor.authorVicaut, Eric
dc.contributor.authorLabreuche, Julien
dc.contributor.authorAcevedo, Monica
dc.contributor.authorTorres, Victor
dc.contributor.authorRamirez Martinez, Jesus
dc.contributor.authorVinueza, Raul
dc.contributor.authorSilva, Honorio
dc.contributor.authorChampagne, Beatriz
dc.contributor.authorHernandez Hernandez, Rafael
dc.contributor.authorWilson, Elinor
dc.contributor.authorSchargrodsky, Herman
dc.contributor.authorCARMELA Study Investigators
dc.date.accessioned2024-01-10T13:46:58Z
dc.date.available2024-01-10T13:46:58Z
dc.date.issued2011
dc.description.abstractBackground: Measurement of far wall common carotid artery intima-media thickness (CCAIMT) has emerged as a predictor of incident cardiovascular events. The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) study was the first large-scale population-based assessment of both CCAIMT and cardiovascular risk factor prevalence in 7 Latin American cities; the relationship between CCAIMT and cardiovascular risk markers was assessed in these urban Latin American centers. Methods: CARMELA was a cross-sectional, population-based, observational study using stratified, multistage sampling. The participants completed a questionnaire, were evaluated in a clinical visit and underwent carotid ultrasonography. Clinical measurements were obtained by health personnel trained, certified and supervised by CARMELA investigators. Mannheim intima-media thickness consensus guidelines were followed for measurement of CCAIMT. Results: In all cities and for both sexes, CCAIMT increased with higher age. CCAIMT was greater in the presence of cardiovascular risk factors than in their absence. In all cities, there was a statistically significant linear trend between increasing CCAIMT and a growing number of cardiovascular risk factors (p < 0.001). After adjustment for age and sex, metabolic syndrome was strongly associated with increased CCAIMT (p < 0.001 in all cities), as were hypercholesterolemia, obesity and diabetes (p < 0.001 in most cities). By multivariate analysis, hypertension was independently associated with an increase in CCAIMT in all cities (p < 0.01). Conclusions: CARMELA was the first large-scale population study to provide normal CCAIMT values according to age and sex in urban Latin American populations and to show CCAIMT increases in the presence of cardiovascular risk factors and metabolic syndrome. Copyright (C) 2010 S. Karger AG, Basel
dc.description.funderPfizer Inc.
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1159/000320264
dc.identifier.eissn1421-9786
dc.identifier.issn1015-9770
dc.identifier.pubmedidMEDLINE:20980753
dc.identifier.urihttps://doi.org/10.1159/000320264
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79219
dc.identifier.wosidWOS:000291814300008
dc.information.autorucMedicina;Acevedo M ;S/I;81173
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final50
dc.pagina.inicio43
dc.publisherKARGER
dc.revistaCEREBROVASCULAR DISEASES
dc.rightsacceso restringido
dc.subjectAtherosclerosis
dc.subjectCardiovascular risk factors
dc.subjectCommon carotid intima-media thickness
dc.subjectCarotid plaque
dc.subjectIntima-media thickness reference values
dc.subjectCORONARY-HEART-DISEASE
dc.subjectMETABOLIC SYNDROME
dc.subjectWALL THICKNESS
dc.subjectATHEROSCLEROSIS
dc.subjectASSOCIATION
dc.subjectSTROKE
dc.subjectDETERMINANTS
dc.subjectHYPERTENSION
dc.subjectPROGRESSION
dc.subjectSURROGATE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCommon Carotid Artery Intima-Media Thickness: The Cardiovascular Risk Factor Multiple Evaluation in Latin America (CARMELA) Study Results
dc.typeartículo
dc.volumen31
sipa.codpersvinculados81173
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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