How Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway

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dc.catalogadorjca
dc.contributor.authorBonansco, Christian
dc.contributor.authorCerpa Nebott, Waldo
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2024-02-27T16:02:46Z
dc.date.available2024-02-27T16:02:46Z
dc.date.issued2022
dc.description.abstractSynaptic transmission is a dynamic process that requires precise regulation. Early in life, we must be able to forge appropriate connections (add and remove) to control our behavior. Neurons must recognize appropriate targets, and external soluble factors that activate specific signaling cascades provide the regulation needed to achieve this goal. Wnt signaling has been implicated in several forms of synaptic plasticity, including functional and structural changes associated with brain development. The analysis of synapses from an electrophysiological perspective allows us to characterize the functional role of cellular signaling pathways involved in brain development. The application of quantal theory to principles of developmental plasticity offers the possibility of dissecting the function of structural changes associated with the birth of new synapses as well as the maturation of immature silent synapses. Here, we focus on electrophysiological and molecular evidence that the Wnt signaling pathway regulates glutamatergic synaptic transmission, specifically N-methyl-d-aspartate receptors (NMDARs), to control the birth of new synapses. We also focus on the role of Wnts in the conversion of silent synapses into functional synapses.
dc.fechaingreso.objetodigital2024-05-06
dc.fuente.origenORCID
dc.identifier.doi10.3390/ijms24010708
dc.identifier.issn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms24010708
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81339
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott, Waldo Francisco; 0000-0001-7344-0144; 16584
dc.information.autorucFacultad de Ciencias Biológicas;Inestrosa Cantin, Nibaldo;S/I;26312
dc.issue.numero708
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final22
dc.pagina.inicio1
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.subjectImmature synapses
dc.subjectSynaptic conversion
dc.subjectDevelopmental plasticity
dc.subjectGluN2B-containing glutamate receptors
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHow Are Synapses Born? A Functional and Molecular View of the Role of the Wnt Signaling Pathway
dc.typeartículo
dc.volumen24
sipa.codpersvinculados16584
sipa.codpersvinculados26312
sipa.trazabilidadORCID;2024-01-15
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