Rotavirus genotypes in children with gastroenteritis assisted in two public hospitals from Chile: viral strains circulating in a country without a universal vaccination against rotavirus

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dc.contributor.authorLucero, Yalda
dc.contributor.authorMamani, Nora
dc.contributor.authorCortes, Hector
dc.contributor.authorPena, Alfredo
dc.contributor.authorVergara, Rodrigo
dc.contributor.authorO'Ryan, Miguel
dc.date.accessioned2024-01-10T12:42:16Z
dc.date.available2024-01-10T12:42:16Z
dc.date.issued2012
dc.description.abstractBackground: Rotavirus is the main cause of severe gastroenteritis (GE) in children. Two vaccines currently available have proven efficacy against the predominant genotypes. Rotavirus genotypes vary both geographically and/or temporally. Genotype surveillance is important to monitor trends associated or not with vaccine use. Aim: To update information on rotavirus genotypes circulating in two main cities of Chile. Methodology: Between May 2009-March 2010, children < 5y of age receiving medical care for GE in two large hospitals were recruited; none of these children had received rotavirus vaccine previously. Epidemiological information was recorded in an ad-hoc form and stool samples were collected for rotavinis detection by a commercial ELISA. Genotyping was performed by semi-nested RT-PCR. Results: A total of 296/967 samples (31%) were positive for rotavirus, with a peak in November/December mostly in children 7-24 months old (67%). G9P[8] was the predominant genotype (76%), followed for G1P[8] (6%) and G2P[4] (6%) in both cities. Conclusions: Rotavirus caused one third of GE requiring emergency room care and/or hospitalization, mostly in children within an age range susceptible to benefit from rotavirus vaccines. G9P[8], a genotype against which rotavirus vaccines have demonstrated high efficacy, was by far the most frequent rotavirus variant. Continued surveillance in Chile is crucial for providing background information on disease burden and strain diversity before the introduction of rotavirus vaccines.
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:22689027
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77496
dc.identifier.wosidWOS:000303085500004
dc.information.autorucMedicina;Pena A;S/I;75347
dc.issue.numero2
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final148
dc.pagina.inicio142
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsregistro bibliográfico
dc.subjectRotavirus
dc.subjectviral genotypes
dc.subjectepidemiology
dc.subjectacute gastroenteritis
dc.subjectvaccine
dc.subjectMOLECULAR EPIDEMIOLOGY
dc.subjectDIARRHEA
dc.subjectVACCINES
dc.subjectSURVEILLANCE
dc.subjectINFECTIONS
dc.subjectEMERGENCE
dc.subjectEFFICACY
dc.subjectAMERICA
dc.subjectVISITS
dc.subjectIMPACT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRotavirus genotypes in children with gastroenteritis assisted in two public hospitals from Chile: viral strains circulating in a country without a universal vaccination against rotavirus
dc.typeartículo
dc.volumen29
sipa.codpersvinculados75347
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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