Associations of the CTLA-4 polymorphism with type 1 diabetes in Chilean population: case-parent design
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Date
2009
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Abstract
CTLA-4 plays a key role in T cells regulation. We analysed the CTLA-4 +49A/G and -318C/T polymorphisms in 178 cases of type 1 diabetes and their parents (534 individuals) from Santiago, Chile. A significant overall association with T1D (p = 0.028) was observed, possibly due to an overtransmission of the G-T haplotype. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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Keywords
CTLA-4, Polymorphism, TDT analysis, Type 1 diabetes