Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats

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dc.contributor.authorDagnino Subiabre, Alexies
dc.contributor.authorOrellana, Juan A.
dc.contributor.authorCarmona Fontaine, Carlos
dc.contributor.authorMontiel, Juan
dc.contributor.authorDiaz Veliz, Gabriela
dc.contributor.authorSeron Ferre, Maria
dc.contributor.authorWyneken, Ursula
dc.contributor.authorConcha, Miguel L.
dc.contributor.authorAboitiz, Francisco
dc.date.accessioned2024-01-10T13:46:48Z
dc.date.available2024-01-10T13:46:48Z
dc.date.issued2006
dc.description.abstractChronic stress affects brain areas involved in learning and emotional responses. Although most studies have concentrated on the effect of stress on limbic-related brain structures, in this study we investigated whether chronic stress might induce impairments in diencephalic structures associated with limbic components of the stress response. Specifically, we analyzed the effect of chronic immobilization stress on the expression of sympathetic markers in the rat epithalamic pineal gland by immunohistochemistry and western blot, whereas the plasma melatonin concentration was determined by radioimmunoassay. We found that chronic stress decreased the expression of three sympathetic markers in the pineal gland, tyrosine hydroxylase, the p75 neurotrophin receptor and alpha-tubulin, while the same treatment did not affect the expression of the non-specific sympathetic markers Erk1 and Erk2, and glyceraldehyde-3-phosphate dehydrogenase. Furthermore, these results were correlated with a significant increase in plasma melatonin concentration in stressed rats when compared with control animals. Our findings indicate that stress may impair pineal sympathetic inputs, leading to an abnormal melatonin release that may contribute to environmental maladaptation. In addition, we propose that the pineal gland is a target of glucocorticoid damage during stress.
dc.description.funderWellcome Trust
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1471-4159.2006.03787.x
dc.identifier.eissn1471-4159
dc.identifier.issn0022-3042
dc.identifier.pubmedidMEDLINE:16539651
dc.identifier.urihttps://doi.org/10.1111/j.1471-4159.2006.03787.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79203
dc.identifier.wosidWOS:000237516700006
dc.information.autorucMedicina;Aboitiz F;S/I;100165
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1287
dc.pagina.inicio1279
dc.publisherWILEY
dc.revistaJOURNAL OF NEUROCHEMISTRY
dc.rightsacceso restringido
dc.subjectdepression
dc.subjectepithalamus
dc.subjectmelatonin
dc.subjectpineal gland
dc.subjectstress
dc.subjectSHREW TUPAIA-BELANGERI
dc.subjectSEROTONIN METABOLISM
dc.subjectPSYCHOSOCIAL STRESS
dc.subjectREACTIVE RESPONSE
dc.subjectMAJOR DEPRESSION
dc.subjectSUBSTANTIA-NIGRA
dc.subjectRECEPTOR
dc.subjectHIPPOCAMPUS
dc.subjectSECRETION
dc.subjectNEURONS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats
dc.typeartículo
dc.volumen97
sipa.codpersvinculados100165
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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