Daily vs. intermittent inhaled corticosteroids for recurrent wheezing and mild persistent asthma : a systematic review with meta-analysis

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dc.contributor.authorRodrigo, Gustavo Javier
dc.contributor.authorCastro Rodríguez, José Antonio
dc.date.accessioned2021-01-14T19:12:55Z
dc.date.available2021-01-14T19:12:55Z
dc.date.issued2013
dc.description.abstractBackground Intermittent ICS treatment with SABA in response to symptoms, is an emerging strategy for control of mild-to-moderate asthma, and recurrent wheezing. This systematic revue compares the efficacy of daily vs. intermittent ICS among preschoolers, children and adults with persistent wheezing and mild to moderate stable persistent asthma. Methods Systematic review of randomized, placebo-controlled trials with a minimum of 8 weeks of daily (daily ICS with rescue SABA during exacerbations) vs. intermittent ICS (ICS plus SABA at the onset of symptoms), were retrieved through different databases. Primary outcome was asthma exacerbations; secondary outcomes were pulmonary function tests, symptoms, days without symptoms, SABA use, corticosteroids use, days without rescue medication use, expired nitric oxide and serious adverse events. Results Seven trials (1367 participants) met inclusion criteria there was no statistically significant difference in the rate of asthma exacerbations between those with daily vs. intermittent ICS (0.96; 95% CI: 0.86, 1.06, I2 = 0%). In the sub-group analysis, no differences were seen in duration of studies, step-up strategy or age. However, compared to intermittent ICS, the daily ICS group had a significant increase in asthma-free days and non-significant decreases in rescue SABA use and exhaled nitric oxide measurement. Conclusions No significant differences between daily and intermittent ICS in reducing the incidence of asthma exacerbations was found. However, the daily ICS strategy was superior in many secondary outcomes. Therefore, this study suggests to not change daily for intermittent ICS use among preschoolers, children with persistent wheezing and adults with mild-to-moderate stable persistent asthma.
dc.format.extent8 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1016/j.rmed.2013.05.005
dc.identifier.issn0954-6111
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2013.05.005
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/50692
dc.information.autorucEscuela de medicina ; Castro Rodríguez, José Antonio ; 0000-0002-0708-4281 ; 113247
dc.issue.numeroNo. 8
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1140
dc.pagina.inicio1133
dc.relation.isformatofRespiratory Medicine, vol. 107, no. 8 (ago. 2013), pp. 1133-1140.
dc.revistaRespiratory Medicinees_ES
dc.rightsacceso abierto
dc.subjectAsthma
dc.subjectDaily
dc.subjectInhaled corticosteroids
dc.subjectIntermittent
dc.subjectTreatment
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherMedicina y salud
dc.titleDaily vs. intermittent inhaled corticosteroids for recurrent wheezing and mild persistent asthma : a systematic review with meta-analysises_ES
dc.typeartículo
dc.volumenVol. 107
sipa.codpersvinculados113247
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