Evolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study

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dc.contributor.authorHernandez, Glenn
dc.contributor.authorPedreros, Cesar
dc.contributor.authorVeas, Enrique
dc.contributor.authorBruhn, Alejandro
dc.contributor.authorRomero, Carlos
dc.contributor.authorRovegno, Maximiliano
dc.contributor.authorNeira, Rodolfo
dc.contributor.authorBravo, Sebastian
dc.contributor.authorCastro, Ricardo
dc.contributor.authorKattan, Eduardo
dc.contributor.authorInce, Can
dc.date.accessioned2024-01-10T13:48:14Z
dc.date.available2024-01-10T13:48:14Z
dc.date.issued2012
dc.description.abstractPurpose: Perfusion assessment during septic shock resuscitation is difficult and usually complex determinations. Capillary refill time (CRT) and central-to-toe temperature difference (Tc-toe) have been proposed as objective reproducible parameters to evaluate peripheral perfusion. The comparative evolution of peripheral vs metabolic perfusion parameters in septic shock resuscitation has not been studied. We conducted a prospective observational clinical-physiologic study to address this subject.
dc.description.abstractMethods: Patients with sepsis-related circulatory dysfunction were resuscitated according to a standard local algorithm. Perfusion assessment included serial determinations of metabolic (central venous O-2 saturation [ScvO(2)] and central venous to arterial PCO2 gradient [P(cv-a)CO2]) and peripheral perfusion parameters (CRT and Tc-toe, among others). Successful resuscitation was defined as a normal plasma lactate at 24 hours.
dc.description.abstractResults: Forty-one patients were included. The presence of normal values for both CRT and Tc-toe considered together at 6 hours was independently associated with a successful resuscitation (P = .02), as compared with the behavior of metabolic parameters. Capillary refill time was the first parameter to be significantly normalized.
dc.description.abstractConclusion: Early recovery of peripheral perfusion anticipates a successful resuscitation compared with traditional metabolic parameters in septic shock patients. Our findings support the inclusion of serial peripheral perfusion assessment in multimodal monitoring strategies for septic shock resuscitation. (C) 2012 Elsevier Inc. All rights reserved.
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jcrc.2011.05.024
dc.identifier.eissn1557-8615
dc.identifier.issn0883-9441
dc.identifier.pubmedidMEDLINE:21798706
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2011.05.024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79346
dc.identifier.wosidWOS:000304872000011
dc.information.autorucMedicina;Bravo S;S/I;172062
dc.information.autorucMedicina;Bruhn A ;S/I;741
dc.information.autorucMedicina;Castro R ;S/I;4537
dc.information.autorucMedicina;Hernandez G ;S/I;98874
dc.information.autorucMedicina;Kattan E ;S/I;172152
dc.information.autorucMedicina;Pedreros C ;S/I;9377
dc.information.autorucMedicina;Rovegno D;S/I;1004053
dc.information.autorucMedicina;Veas E;S/I;18259
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final288
dc.pagina.inicio283
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaJOURNAL OF CRITICAL CARE
dc.rightsacceso restringido
dc.subjectPeripheral perfusion
dc.subjectSeptic shock
dc.subjectLactate
dc.subjectResuscitation
dc.subjectGOAL-DIRECTED THERAPY
dc.subjectVENOUS OXYGEN-SATURATION
dc.subjectINTENSIVE-CARE-UNIT
dc.subjectSEVERE SEPSIS
dc.subjectSUBJECTIVE ASSESSMENT
dc.subjectMANAGEMENT
dc.subjectHYPOPERFUSION
dc.subjectTEMPERATURE
dc.subjectMULTICENTER
dc.subjectSURVIVAL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvolution of peripheral vs metabolic perfusion parameters during septic shock resuscitation. A clinical-physiologic study
dc.typeartículo
dc.volumen27
sipa.codpersvinculados172062
sipa.codpersvinculados741
sipa.codpersvinculados4537
sipa.codpersvinculados98874
sipa.codpersvinculados172152
sipa.codpersvinculados9377
sipa.codpersvinculados1004053
sipa.codpersvinculados18259
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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