Multimodal assessment of acute cardiac toxicity induced by thoracic radiotherapy in cancer patients : study protocol

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dc.article.number1114
dc.contributor.authorMerino Lara, Tomas Rodrigo
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorOrellana Vargas, María Paz
dc.contributor.authorMartínez, Gonzalo
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.contributor.authorMuñoz Schuffenegger, Pablo
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorGabrielli, Luigi
dc.contributor.authorSánchez Rojel, César Giovanni
dc.contributor.authorPereira, Jaime
dc.date.accessioned2021-11-17T22:53:14Z
dc.date.available2021-11-17T22:53:14Z
dc.date.issued2021
dc.date.updated2021-10-24T00:02:11Z
dc.description.abstractBackground : Today, cancer ranks as one of the leading causes of death. Despite the large number of novel available therapies, radiotherapy (RT) remains as the most effective non-surgical method to cure cancer patients. In fact, approximately 50% of all cancer patients receive some type of RT and among these 60% receive RT-treatment with a curative intent. However, as occurs with any other oncological therapy, RT treated patients may experience toxicity side effects that range from moderate to severe. Among these, cardiotoxicity represents a significant threat for premature death. Current methods evaluate cardiotoxic damage based on volumetric changes in the Left Ventricle Ejected Fraction (LVEF). Indeed, a 10% drop in LVEF is commonly used as indicator of cardiotoxicity. More recently, a number of novel techniques have been developed that significantly improve specificity and sensitivity of heart’s volumetric changes and early detection of cardiotoxicity even in asymptomatic patients. Among these, the Strain by Speckle Tracking (SST) is a technique based on echocardiographic analysis that accurately evaluates myocardial deformation during the cardiac cycle (ventricular and atrial function). Studies also suggest that Magnetic Resonance Imaging (MRI) is a high-resolution technique that enables a better visualization of acute cardiac damage. Methodology: This protocol will evaluate changes in SST and MRI in cancer patients that received thoracic RT. Concomitantly, we will assess changes in serum biomarkers of cardiac damage in these patients, including: high-sensitivity cardiac Troponin-T (hscTnT), N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) and Circulating Endothelial Cells (CECs), a marker of endothelial dysfunction and vascular damage. Discussion: The presented protocol is to our knowledge the first to prospectively and with a multimodal approach, study serological and image biomarkers off early cardiac damage due to radiotherapy. With a practical clinical approach we will seek early changes that could potentially be in the future be linked to clinical mayor events with consequences for cancer survivors.
dc.format.extent9 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationBMC Cancer. 2021 Oct 18;21(1):1114
dc.identifier.doi10.1186/s12885-021-08823-3
dc.identifier.urihttps://doi.org/10.1186/s12885-021-08823-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/62961
dc.information.autorucEscuela de Medicina ; Merino, Tomás ; 0000-0003-3661-9123 ; 119017
dc.information.autorucEscuela de Medicina ; Pinto, Mauricio P. ; 0000-0003-2484-8033 ; 84790
dc.information.autorucEscuela de Medicina ; Orellana Vargas, María Paz ; S/I ; 9307
dc.information.autorucEscuela de Medicina ; Martínez, Gonzalo ; 0000-0003-3379-580X ; 190229
dc.information.autorucEscuela de Medicina ; Andía Kohnenkampf, Marcelo Edgardo ; 0000-0002-1251-5832 ; 90691
dc.information.autorucEscuela de Medicina ; Muñoz Schuffenegger, Pablo ; 0000-0002-9687-5404 ; 132763
dc.information.autorucEscuela de Medicina ; Acevedo Claros, Francisco Nicolás ; 0000-0003-3482-7746 ; 119540
dc.information.autorucEscuela de Medicina ; Gabrielli, Luigi ; 0000-0002-1551-7147 ; 11086
dc.information.autorucEscuela de Medicina ; Sánchez Rojel, César Giovanni ; 0000-0002-2920-108X ; 135644
dc.information.autorucEscuela de Medicina ; Pereira, Jaime ; 0000-0003-0481-328X ; 15456
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final9
dc.pagina.inicio1
dc.revistaBMC Cancer
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subjectRadiotherapyes_ES
dc.subjectCanceres_ES
dc.subjectCardio-oncologyes_ES
dc.subjectEchocardiographyes_ES
dc.subjectMagnetic cardiac resonancees_ES
dc.subjectCirculating endothelial cellses_ES
dc.subjectPredictorses_ES
dc.subjectCardiotoxicityes_ES
dc.subject.ddc615.842
dc.subject.deweyMedicina y saludes_ES
dc.titleMultimodal assessment of acute cardiac toxicity induced by thoracic radiotherapy in cancer patients : study protocoles_ES
dc.typeartículo
dc.volumen21
sipa.codpersvinculados119017
sipa.codpersvinculados84790
sipa.codpersvinculados9307
sipa.codpersvinculados190229
sipa.codpersvinculados90691
sipa.codpersvinculados132763
sipa.codpersvinculados119540
sipa.codpersvinculados11086
sipa.codpersvinculados135644
sipa.codpersvinculados15456
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