Genetics of biliary lithiasis from an ethnic perspective

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dc.catalogadorjlo
dc.contributor.authorKrawczyk, Marcin
dc.contributor.authorMiquel Poblete, Juan Francisco
dc.contributor.authorStokes, Caroline S.
dc.contributor.authorZuniga, Silvia
dc.contributor.authorHampe, Jochen
dc.contributor.authorMittal, Balraj
dc.contributor.authorLammert, Frank
dc.date.accessioned2024-08-06T19:42:11Z
dc.date.available2024-08-06T19:42:11Z
dc.date.issued2013
dc.description.abstractGallstone disease represents one of the most common gastroenterological disorders worldwide. Gallstones affect over 15% of adults in Europe and 25-30% of Hispanic populations in Central and South America. The heritability of gallstones varies considerably according to ethnicity, with Native Americans and Hispanics with Amerindian admixture being the most susceptible populations. Genetic factors have been shown to account for 25-30% of total gallstone risk in Europe, however, in Hispanic populations, this risk percentage may increase to 45-65%. Recent genome-wide association and candidate gene studies have identified common polymorphisms in enterohepatic transporters (ABCG5/8, SLC10A2) and the Gilbert syndrome UGT1A1 variant as genetic determinants of gallstone formation. Together, these polymorphisms cover a significant proportion of the previously predicted genetic background of gallstones in European populations. New lithogenic genes need to be discovered in future studies in high-risk populations. In this review, we address the latest developments in the genetic analysis of gallstones and discuss the ethnic background of this condition in European, Central and South American and Asian populations. (C) 2012 Elsevier Masson SAS. All rights reserved.
dc.format.extent7 páginas
dc.fuente.origenConveris
dc.identifier.doi10.1016/j.clinre.2012.09.002
dc.identifier.eissn2210-741X
dc.identifier.issn2210-741X
dc.identifier.urihttp://dx.doi.org/10.1016/j.clinre.2012.09.002
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87295
dc.information.autorucEscuela de Medicina; Miquel Poblete, Juan Francisco; 0000-0002-0526-4377; 72216
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final125
dc.pagina.inicio119
dc.revistaClinics and Research in Hepatology and Gastroenterology
dc.rightsacceso restringido
dc.subjectATP-Binding Cassette Transporters
dc.subjectCentral America
dc.subjectContinental Population Groups
dc.subjectGallstones
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleGenetics of biliary lithiasis from an ethnic perspective
dc.typeartículo
dc.volumen37
sipa.codpersvinculados72216
sipa.trazabilidadConveris;20-07-2021
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