Fisiopatología de la retinopatía y nefropatía diabéticas

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dc.catalogadorpau
dc.contributor.authorOlmos Coelho, Pablo Roberto
dc.contributor.authorAraya del Pino, Andrea Paz
dc.contributor.authorGonzález Carvallo, Cristian
dc.contributor.authorLaso Ulloa, Pablo
dc.contributor.authorIrribarra Pastenes, Verónica
dc.contributor.authorRubio Quiroz, Lorena Alejandra
dc.date.accessioned2023-07-21T17:46:08Z
dc.date.available2023-07-21T17:46:08Z
dc.date.issued2009
dc.description.abstractDespite the availability of multiple therapeutic approaches, diabetes mellitus with chronic hyperglycemia remains as the main cause of new cases of blindness and chronic renal failure in the western hemisphere. We herein review the molecular mechanisms by which chronic hyperglycemia causes retinopathy and nephropathy in type I and type 2 diabetic patients. Diabetic retinopathy develops silently along years or decades, producing symptoms only in its very late stages. Its slow development starts with the activation of aldose reductase, shortly followed by the destruction of the retinal pericyte cells, and ends in sudden blindness when vitreous hemorrhage ensues. Nephropathy, on the other hand, centers its pathophysiology in the mesangial cell, that starts as a modified smooth-muscle cell, and turns itself into a myo-fibroblast, produces such amounts of cytoplasm and extracellular protein that strangulates the glomerular capillaries and causes renal failure. After a detailed review of the molecular mechanisms of the aforementioned complications, we conclude that, apart from directing our attention to the emerging medications that are being developed to block these molecular pathways, we should never abandon the struggle for improving the glycemic control of our diabetic patients
dc.fechaingreso.objetodigital2024-04-11
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.4067/S0034-98872009001000015
dc.identifier.issn0034-9887
dc.identifier.urihttp://dx.doi.org/10.4067/S0034-98872009001000015
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-71149101848&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74246
dc.information.autorucEscuela de Medicina; Olmos Coelho, Pablo Roberto; S/I; 98949
dc.information.autorucEscuela de Medicina; Araya del Pino, Andrea Paz; 0000-0002-2073-5501; 132727
dc.information.autorucEscuela de Medicina; González Carvallo, Cristian; S/I; 132736
dc.information.autorucEscuela de Medicina; Laso Ulloa, Pablo; S/I; 132726
dc.information.autorucEscuela de Medicina; Irribarra Pastenes, Verónica; S/I; 366
dc.information.autorucFacultad de Ciencias Biológicas; Rubio Quiroz, Lorena Alejandra; S/I; 11591
dc.issue.numero10
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1384
dc.pagina.inicio1375
dc.revistaRevista médica de Chilees_ES
dc.rightsacceso abierto
dc.subjectDiabetes mellitus
dc.subjectDiabetic nephropathy
dc.subjectDiabetic retinopathy
dc.titleFisiopatología de la retinopatía y nefropatía diabéticases_ES
dc.titleFisiopatología de la retinopatía y nefropatía diabéticas
dc.title.alternativePathophysiology of diabetic retinopathy and nephropathyes_ES
dc.typeartículo
dc.volumen137
sipa.codpersvinculados98949
sipa.codpersvinculados132727
sipa.codpersvinculados132736
sipa.codpersvinculados132726
sipa.codpersvinculados366
sipa.codpersvinculados11591
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