Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile

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dc.contributor.authorCastillo, Andres
dc.contributor.authorAguayo, Francisco
dc.contributor.authorKoriyama, Chihaya
dc.contributor.authorTorres, Miyerlandi
dc.contributor.authorCarrascal, Edwin
dc.contributor.authorCorvalan, Alejandro
dc.contributor.authorRoblero, Juan P.
dc.contributor.authorNaquira, Cecilia
dc.contributor.authorPalma, Mariana
dc.contributor.authorBackhouse, Claudia
dc.contributor.authorArgandona, Jorge
dc.contributor.authorItoh, Tetsuhiko
dc.contributor.authorShuyama, Karem
dc.contributor.authorEizuru, Yoshito
dc.contributor.authorAkiba, Suminori
dc.date.accessioned2024-01-10T13:49:09Z
dc.date.available2024-01-10T13:49:09Z
dc.date.issued2006
dc.description.abstractAIM: To examine the presence of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC) specimens collected from Colombia and Chile located in the northern and southern ends of the continent, respectively.
dc.description.abstractMETHODS: We examined 47 and 26 formalin-fixed and paraffin-embedded ESCC specimens from Colombia and Chile, respectively. HPV was detected using GP5+/GP6+ primer pair for PCR, and confirmed by Southern blot analysis. Sequencing analysis of L1 region fragment was used to identify HPV genotype. In addition, P16(INK4A) protein immunostaining of all the specimens was conducted.
dc.description.abstractRESULTS: HPV was detected in 21 ESCC specimens (29%). Sequencing analysis of L1 region fragment identified HPV-16 genome in 6 Colombian cases (13%) and in 5 Chilean cases (19%). HPV-18 was detected in 10 cases (21%) in Colombia but not in any Chilean case. Since Chilean ESCC cases had a higher prevalence of HPV-16 (without statistical significance), but a significantly lower prevalence of HPV-18 than in Colombian cases (P = 0.011) even though the two countries have similar ESCC incidence rates, the frequency of HPV-related ESCC may not be strongly affected by risk factors affecting the incidence of ESCC. HPV-16 genome was more frequently detected in p16 positive carcinomas, although the difference was not statistically significant. HPV-18 detection rate did not show any association with p16 expression. Well-differentiated tumors tended to have either HPV-16 or HPV-18 but the association was not statistically significant. HPV genotypes other than HPV-16 or 18 were not detected in either country.
dc.description.abstractCONCLUSION: HPV-16 and HPV-18 genotypes can be found in ESCC specimens collected from two South American countries. Further studies on the relationship between HPV-16 presence and p16 expression in ESCC would aid understanding of the mechanism underlying the presence of HPV in ESCC. (C) 2006 The WJG Press. All rights reserved.
dc.fechaingreso.objetodigital2024-05-27
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3748/wjg.v12.i38.6188
dc.identifier.issn1007-9327
dc.identifier.pubmedidMEDLINE:17036393
dc.identifier.urihttps://doi.org/10.3748/wjg.v12.i38.6188
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79427
dc.identifier.wosidWOS:000241371400017
dc.information.autorucMedicina;Corvalán A;S/I;63885
dc.issue.numero38
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final6192
dc.pagina.inicio6188
dc.publisherW J G PRESS
dc.revistaWORLD JOURNAL OF GASTROENTEROLOGY
dc.rightsacceso abierto
dc.subjecthuman papillomavirus
dc.subjectesophageal squamous cell cancer
dc.subjectColombia
dc.subjectChile
dc.subjectTYPE-16 INFECTION
dc.subjectGENERAL PRIMERS
dc.subjectCANCER
dc.subjectPOPULATION
dc.subjectINHIBITION
dc.subjectEXPRESSION
dc.subjectCHINA
dc.subjectCARCINOGENESIS
dc.subjectPREVALENCE
dc.subjectMORTALITY
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleHuman papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile
dc.typeartículo
dc.volumen12
sipa.codpersvinculados63885
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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