Motor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in Labor

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dc.contributor.authorLacassie, Hector J.
dc.contributor.authorHabib, Ashraf S.
dc.contributor.authorLacassie, Hector P.
dc.contributor.authorColumb, Malachy O.
dc.date.accessioned2024-01-10T12:40:39Z
dc.date.available2024-01-10T12:40:39Z
dc.date.issued2007
dc.description.abstractBackground and objectives: Adequate comparison of blocking capabilities of local anesthetics should be done with some knowledge of their relative potencies. The objective of this clinical trial was to simultaneously determine the motor blocking minimum local anesthetic concentrations (MMLAC) and the relative potency ratios for racemic bupivacaine, levobupivacaine, and ropivacame during labor.
dc.description.abstractMethods: We studied parturients with singleton term pregnancies in vertex presentation. Each patient received a 20 mL epidural bolus of bupivacaine, levobupivacaine, or ropivacaine determined by the MMLAC model. Baseline and 30 min after injection, measurements of pain and muscle strength were performed, with assessment of motor strength in the legs at 30 min being the primary outcome measure.
dc.description.abstractResults: There were no differences in demographic, hemodynamic, or obstetric characteristics between the patients receiving the three local anesthetics. The estimated MMLAC with the 95% confidence intervals (Cl) were: Bupivacaine: 0.26% wt/vol (0.22-0.30); Levobupivacaine: 0.30% wt/vol (0.25-0.36); Ropivacaine: 0.34% wt/vol (0.29-0.38). ANOVA of MMLAC estimates was significant (F = 3.32, P =.046), and when ranked by analgesic potencies, a significant linear trend (P =.0 14) to increasing motor blocking potencies from ropivacaine to levobupivacaine to bupivacaine was also found.
dc.description.abstractConclusions: This study confirms a motor blocking hierarchy for the three pipe col oxylidines.
dc.fechaingreso.objetodigital09-04-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.rapm.2007.05.003
dc.identifier.issn1098-7339
dc.identifier.pubmedidMEDLINE:17720117
dc.identifier.urihttps://doi.org/10.1016/j.rapm.2007.05.003
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77333
dc.identifier.wosidWOS:000249513500009
dc.information.autorucMedicina;Lacassie H;S/I;68956
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final329
dc.pagina.inicio323
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.revistaREGIONAL ANESTHESIA AND PAIN MEDICINE
dc.rightsacceso restringido
dc.subjectminimum local anesthetic concentration
dc.subjectlabor
dc.subjectmotor block
dc.subjectRELATIVE POTENCIES
dc.subjectANALGESIA
dc.titleMotor blocking minimum local anesthetic concentrations of bupivacaine, levobupivacaine, and ropivacaine in Labor
dc.typeartículo
dc.volumen32
sipa.codpersvinculados68956
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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