Factors predictive of thrombotic events in LUMINA, a multi-ethnic cohort of SLE patients (LXXII)

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dc.contributor.authorBurgos, Paula I.
dc.contributor.authorMcGwin, Gerald, Jr.
dc.contributor.authorReveille, John D.
dc.contributor.authorVila, Luis M.
dc.contributor.authorAlarcon, Graciela S.
dc.date.accessioned2024-01-10T13:48:20Z
dc.date.available2024-01-10T13:48:20Z
dc.date.issued2010
dc.description.abstractMethod. SLE patients (ACR criteria), age epsilon 16 years, disease duration 5 years at enrolment (T0), African-American, Hispanic (Texan or Puerto Rican) or Caucasian ethnicity, from LUMINA, a longitudinal cohort, were studied. An event was defined as the presence of arterial or venous thrombosis. Time to the first thrombotic event was examined by univariable and multivariable (MV) Cox models adjusting for pertinent baseline clinical and socio-demographic variables.
dc.description.abstractResults. A total of 643 patients were studied; mean (s.d.) age was 36.4 (12.6) years and disease duration at T0 was 1.4 (1.3) years; 90% were female. After T0, 81 (12.6%) patients had developed a thrombotic event. In the MV model, age [hazard ratio (HR) = 1.06; 95% CI 1.03, 1.08; P < 0.0001], health insurance (HR = 0.53; 95% CI 0.30, 0.94; P = 0.029), smoking (HR = 1.85; 95% CI 1.01, 3.40; P = 0.048), damage (T0) (HR = 1.44; 95% CI 1.20, 1.71; P < 0.0001), aPL (HR = 2.12; 95% CI 1.19, 3.76; P = 0.011) and glucocorticoid (highest dose) (HR = 1.01; 95% CI 1.01, 1.02; P < 0.0001) were significant.
dc.description.abstractConclusions. Age, poverty, smoking, damage accrual, aPL and higher doses of glucocorticoids were independently associated with a shorter time to the first thrombotic event; health insurance had a protective effect. Acting upon modifiable risk factors at the personal (smoking, high-dose glucocorticoids) and societal (poverty, health insurance) levels may prevent these events and improve the long-term outcome of SLE patients.
dc.description.funderNational Institute of Arthritis and Musculoskeletal and Skin Disease
dc.description.funderGeneral Clinical Research Centers
dc.description.funderNational Center for Research Resources (NCRR/HIH) RCMI Clinical Research Infrastructure Initiative (RCRII)
dc.description.funderPrograma de Postgrado Becas Chile
dc.description.funderNATIONAL CENTER FOR RESEARCH RESOURCES
dc.description.funderNATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
dc.fechaingreso.objetodigital2024-04-29
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/rheumatology/keq140
dc.identifier.eissn1462-0332
dc.identifier.issn1462-0324
dc.identifier.pubmedidMEDLINE:20498010
dc.identifier.urihttps://doi.org/10.1093/rheumatology/keq140
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79355
dc.identifier.wosidWOS:000280904400016
dc.information.autorucMedicina;Burgos PI;S/I;93093
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1725
dc.pagina.inicio1720
dc.publisherOXFORD UNIV PRESS
dc.revistaRHEUMATOLOGY
dc.rightsacceso restringido
dc.subjectSystemic lupus erythematosus
dc.subjectThrombotic events
dc.subjectRisk factors
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUS
dc.subject3 ETHNIC-GROUPS
dc.subjectANTIPHOSPHOLIPID ANTIBODIES
dc.subjectNATURAL-HISTORY
dc.subjectRISK-FACTORS
dc.subjectDISEASE
dc.subjectRELIABILITY
dc.subjectPREVALENCE
dc.subjectACTIVATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFactors predictive of thrombotic events in LUMINA, a multi-ethnic cohort of SLE patients (LXXII)
dc.typeartículo
dc.volumen49
sipa.codpersvinculados93093
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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