SARS-CoV-2 vaccine booster in solid organ transplant recipients previously immunised with inactivated versus mRNA vaccines: A prospective cohort study

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dc.article.number100371
dc.catalogadorgjm
dc.contributor.authorDib Marambio, Martín Javier
dc.contributor.authorLe Corre Pérez, Monique Nicole
dc.contributor.authorOrtiz Koh, Catalina Alejandra
dc.contributor.authorGarcía, Daniel
dc.contributor.authorFerrés, Marcela
dc.contributor.authorMartínez Valdebenito, Constanza
dc.contributor.authorRuiz-Tagle, Cinthya
dc.contributor.authorOjeda Valenzuela, María José
dc.contributor.authorEspinoza Sepúlveda, Manuel Antonio
dc.contributor.authorJara Contreras, Aquiles
dc.contributor.authorArab Verdugo, Juan Pablo
dc.contributor.authorRabagliati B., Ricardo
dc.contributor.authorVizcaya Altamirano, Cecilia
dc.contributor.authorCeballos, María Elena
dc.contributor.authorSarmiento Maldonado, Mauricio
dc.contributor.authorMondaca Contreras, Sebastián Patricio
dc.contributor.authorViñuela Morales, Macarena Rocío
dc.contributor.authorPastore Thomson, Antonia
dc.contributor.authorSzwarcfiter Neiman, Vania
dc.contributor.authorGaldames Lavín, Elizabeth Alejandra
dc.contributor.authorBarrera Vásquez, Aldo Vincent
dc.contributor.authorCastro Gálvez, Pablo Federico
dc.contributor.authorGálvez Arriagada, Nicolás Marcelo Salvador
dc.contributor.authorSoto Ramírez, Jorge Andrés
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorNervi Nattero, Bruno
dc.contributor.authorBalcells Marty, María Elvira
dc.date.accessioned2022-11-23T15:28:49Z
dc.date.available2022-11-23T15:28:49Z
dc.date.issued2022
dc.description.abstractSolid-organ transplant (SOT) recipients have worse COVID-19 outcomes than general population and effective immunisation in these patients is essential but more difficult to reach. We aimed to determine the immunogenicity of an mRNA SARS-CoV-2 vaccine booster in SOT recipients previously immunised with either inactivated or homologous SARS-CoV-2 mRNA vaccine. Methods: Prospective cohort study of SOT recipients under medical care at Red de Salud UC-CHRISTUS, Chile, previously vaccinated with either CoronaVac or BNT162b2. All participants received a BNT162b2 vaccine booster. The primary study end point was anti-SARS-CoV-2 total IgG antibodies (TAb) seropositivity at 8-12 weeks (56-84 days) post booster. Secondary end points included neutralising antibodies (NAb) and specific T-cell responses. Findings: A total of 140 (50% kidney, 38% liver, 6% heart) SOT recipients (mean age 54 [13.6] years; 64 [46%] women) were included. Of them, 62 had homologous (three doses of BNT162b2) and 78 heterologous vaccine schedules (two doses of CoronaVac followed by BNT162b2 booster). Boosters were received at a median of 21.3 weeks after primary vaccination. The proportion achieving TAb seropositivity (82.3% vs 65.4%, P = 0.035) and NAb positivity (77.4% vs 55.1%, P = 0.007) were higher for the homologous versus the heterologous group. On the other hand, the number of IFN-γ and IL-2 secreting SARS-CoV-2-specific T-cells did not differ significantly between groups. Interpretation: This cohort study shows that homologous mRNA vaccine priming plus boosting in SOT recipients, reaches a significantly higher humoral immune response than inactivated SARS-CoV-2 vaccine priming followed by heterologous mRNA booster.
dc.description.funderANID-Millennium Science Initiative Program ICN09_016
dc.description.funderLa Jolla Institute for Immunology
dc.description.funderLaboratorio de Infectología y Virología Molecular
dc.description.funderRed de Salud UC-CHRISTUS
dc.description.funderSchool of Medicine
dc.description.funderPontificia Universidad Católica de Chile
dc.description.funderANID
dc.fechaingreso.objetodigital2023-11-09
dc.fuente.origenSCOPUS
dc.identifier.doi10.1016/j.lana.2022.100371
dc.identifier.issn2667-193X
dc.identifier.scopusidSCOPUS_ID:85138592528
dc.identifier.urihttps://doi.org/10.1016/j.lana.2022.100371
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75262
dc.information.autorucEscuela de Medicina; Dib Marambio, Martín Javier; S/I; 1103640
dc.information.autorucEscuela de Medicina; Le Corre Pérez, Monique Nicole; 0000-0002-9361-4049; 6737
dc.information.autorucEscuela de Medicina; Ortiz Koh, Catalina Alejandra; S/I; 1094790
dc.information.autorucEscuela de Medicina; Ferrés, Marcela; 0000-0001-9415-4657; 66180
dc.information.autorucEscuela de Medicina; Martínez Valdebenito, Constanza; S/I; 1007539
dc.information.autorucEscuela de Medicina; Ruiz-Tagle, Cinthya; S/I; 1098594
dc.information.autorucEscuela de Medicina; Ojeda Valenzuela, María José; S/I; 1124120
dc.information.autorucEscuela de Medicina; Espinoza Sepúlveda, Manuel Antonio; 0000-0001-9564-9512; 10720
dc.information.autorucEscuela de Medicina; Jara Contreras, Aquiles; S/I; 99877
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.information.autorucEscuela de Medicina; Rabagliati B., Ricardo; S/I; 59169
dc.information.autorucEscuela de Medicina; Vizcaya Altamirano, Cecilia; 0000-0003-1309-9778; 7645
dc.information.autorucEscuela de Medicina; Ceballos, María Elena; 0000-0002-5569-6485; 190187
dc.information.autorucEscuela de Medicina; Sarmiento Maldonado, Mauricio; 0000-0003-3715-9886; 167160
dc.information.autorucEscuela de Medicina; Mondaca Contreras, Sebastián Patricio; 0000-0002-1130-0370; 190152
dc.information.autorucEscuela de Medicina; Viñuela Morales, Macarena Rocío; S/I; 1028006
dc.information.autorucEscuela de Medicina; Pastore Thomson, Antonia; S/I; 234544
dc.information.autorucEscuela de Medicina; Szwarcfiter Neiman, Vania; S/I; 1066967
dc.information.autorucEscuela de Enfermería; Galdames Lavín, Elizabeth Alejandra; S/I; 149858
dc.information.autorucFacultad de Ciencias Biológicas; Barrera Vásquez, Aldo Vincent; S/I; 1031200
dc.information.autorucEscuela de Medicina; Castro Gálvez, Pablo Federico; S/I; 100212
dc.information.autorucFacultad de Ciencias Biológicas; Gálvez Arriagada, Nicolás Marcelo Salvador; 0000-0003-2046-7882; 215440
dc.information.autorucFacultad de Ciencias Biológicas; Soto Ramírez, Jorge Andrés; 0000-0003-0335-9759; 237269
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucEscuela de Medicina; Nervi Nattero, Bruno; 0000-0002-3016-7261; 604
dc.information.autorucEscuela de Medicina; Balcells Marty, María Elvira; 0000-0002-7223-9665; 7462
dc.language.isoen
dc.nota.accesoContenido completo
dc.relation.ispartofLancet Regional Health - Americas
dc.revistaThe Lancet Regional Health - Americas
dc.rightsacceso abierto
dc.subjectBNT162b2
dc.subjectCoronaVac
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectSolid organ transplant
dc.subjectVaccine
dc.subjectVaccine immunogenicity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleSARS-CoV-2 vaccine booster in solid organ transplant recipients previously immunised with inactivated versus mRNA vaccines: A prospective cohort study
dc.typeartículo
dc.volumen16
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sipa.indexSCOPUS
sipa.trazabilidadSCOPUS;10-11-2022
sipa.trazabilidadORCID;2023-11-06
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