Beta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: a Pilot Study

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dc.catalogadorjlo
dc.contributor.authorEscalona Solari, José Antonio
dc.contributor.authorSoto Muñoz, Dagoberto Igor
dc.contributor.authorOviedo Álvarez, Vanessa Andrea
dc.contributor.authorRivas Garrido, Elizabeth Alexis
dc.contributor.authorSeverino, Nicolás
dc.contributor.authorKattan Tala, Eduardo José
dc.contributor.authorAndresen Hernández, Max Alfonso
dc.contributor.authorBravo Morales, Sebastián Ignacio
dc.contributor.authorBasoalto Escobar, Roque Ignacio
dc.contributor.authorBachmann Barron, María Consuelo
dc.contributor.authorKwok-Yin, Wong
dc.contributor.authorPavez, Nicolás
dc.contributor.authorBruhn Cruz, Alejandro Rodrigo
dc.contributor.authorBugedo Tarraza, Guillermo Jaime
dc.contributor.authorRetamal Montes, Jaime Alejandro
dc.date.accessioned2023-07-26T20:11:00Z
dc.date.available2023-07-26T20:11:00Z
dc.date.issued2023
dc.description.abstractDifferent techniques have been proposed to measure antibiotic levels within the lung parenchyma; however, their use is limited because they are invasive and associated with adverse effects. We explore whether beta-lactam antibiotics could be measured in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and correlated with the concentration of antibiotics measured from bronchoalveolar lavage (BAL). We designed an observational study in patients undergoing mechanical ventilation, which required a BAL to confirm or discard the diagnosis of pneumonia. We measured and correlated the concentration of beta-lactam antibiotics in plasma, epithelial lining fluid (ELF), and exhaled breath condensate collected from HMEFs. We studied 12 patients, and we detected the presence of antibiotics in plasma, ELF, and HMEFs from every patient studied. The concentrations of antibiotics were very heterogeneous over the population studied. The mean antibiotic concentration was 293.5 (715) ng/mL in plasma, 12.3 (31) ng/mL in ELF, and 0.5 (0.9) ng/mL in HMEF. We found no significant correlation between the concentration of antibiotics in plasma and ELF (R2 = 0.02, p = 0.64), between plasma and HMEF (R2 = 0.02, p = 0.63), or between ELF and HMEF (R2 = 0.02, p = 0.66). We conclude that beta-lactam antibiotics can be detected and measured from the exhaled breath condensate accumulated in the HMEF from mechanically ventilated patients. However, no correlations were observed between the antibiotic concentrations in HMEF with either plasma or ELF.
dc.fechaingreso.objetodigital2023-07-26
dc.format.extent11 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/jpm13071146
dc.identifier.issn2075-4426
dc.identifier.urihttps://www.mdpi.com/2075-4426/13/7/1146
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74325
dc.information.autorucEscuela de Medicina; Escalona Solari, José Antonio; 0009-0008-0766-4850; 1015488
dc.information.autorucEscuela de Medicina; Soto Muñoz, Dagoberto Igor; 0000-0002-7350-1530; 1008458
dc.information.autorucEscuela de Medicina; Oviedo Álvarez, Vanessa Andrea; S/I; 1009275
dc.information.autorucEscuela de Medicina; Rivas Garrido, Elizabeth Alexis; S/I; 1011538
dc.information.autorucEscuela de Medicina; Kattan Tala, Eduardo José; 0000-0002-1997-6893; 172152
dc.information.autorucEscuela de Medicina; Andresen Hernández, Max Alfonso; 0000-0003-1874-1416; 54274
dc.information.autorucEscuela de Medicina; Bravo Morales, Sebastián Ignacio; 0000-0003-0998-8433; 13431
dc.information.autorucEscuela de Medicina; Basoalto Escobar, Roque Ignacio; S/I; 1010703
dc.information.autorucEscuela de Medicina; Bachmann Barron, María Consuelo; 0000-0002-2006-0591; 215825
dc.information.autorucEscuela de Medicina; Bruhn Cruz, Alejandro Rodrigo; 0000-0001-8034-1937; 741
dc.information.autorucEscuela de Medicina; Bugedo Tarraza, Guillermo Jaime; 0000-0001-7527-6202; 60490
dc.information.autorucEscuela de Medicina; Retamal Montes, Jaime Alejandro; 0000-0002-6817-3659; 175147
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaJournal of Personalized Medicine
dc.rightsacceso abierto
dc.subjectExhaled breath condensate
dc.subjectAntibiotics
dc.subjectPneumonia
dc.subjectHeat and moisture exchange filter
dc.subjectMechanical ventilation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleBeta-Lactam Antibiotics Can Be Measured in the Exhaled Breath Condensate in Mechanically Ventilated Patients: a Pilot Study
dc.typeartículo
dc.volumen13
sipa.codpersvinculados1009848
sipa.codpersvinculados1015488
sipa.codpersvinculados1008458
sipa.codpersvinculados1009275
sipa.codpersvinculados1011538
sipa.codpersvinculados172152
sipa.codpersvinculados54274
sipa.codpersvinculados13431
sipa.codpersvinculados1010703
sipa.codpersvinculados215825
sipa.codpersvinculados741
sipa.codpersvinculados60490
sipa.codpersvinculados175147
sipa.trazabilidadORCID;2023-07-24
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