Quantitative Airway Assessment on Computed Tomography in Patients with alpha(1)-antitrypsin Deficiency

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dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorNewell, John D.
dc.contributor.authorSandhaus, Robert A.
dc.contributor.authorMergo, Patricia J.
dc.contributor.authorBrantly, Mark L.
dc.contributor.authorMurayama, Sadayuki
dc.contributor.authorReilly, John J.
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorWashko, George R.
dc.date.accessioned2024-01-10T12:07:52Z
dc.date.available2024-01-10T12:07:52Z
dc.date.issued2009
dc.description.abstractThe relationship between quantitative airway measurements on computed tomography (CT) and airflow limitation in individuals with severe alpha(1)-antitrypsin deficiency (AATD) is undefined. Thus, we planned to clarity the relationship between CT-based airway indices and airflow limitation in AATD. 52 patients with AATD underwent chest CT and pre-bronchodilator spirometry at three institutions. In the right upper (RUL) and lower (RLL) lobes, wall area percent (WA%) and luminal area (Ai) were measured in the third, fourth, and fifth generations of the bronchi. The severity of emphysema was also calculated in each lobe and expressed as low attenuation area percent (LAA%). Correlations between obtained measurements and FEV1% predicted (FEV1%P) were evaluated by the Spearman rank correlation test. In RUL, WA% of all generations was significantly correlated with FEV1%P (3rd, R = -0.33, p = 0.02; 4th, R = -0.39, p = 0.004; 5th, R = -0.57, p < 0.001; respectively). Ai also showed significant correlations (3rd, R = 0.32, p = 0.02; 4th, R = 0.34, p = 0.01; 5th, R = 0.56, p < 0.001; respectively). Measured correlation coefficients improved when the airway progressed distally from the third to fifth generations. LAA% also correlated with FEV1%P (R = -0.51, p < 0.001). In RLL, WA% showed weak correlations with FEV1%P in all generations (3rd, R = -0.34, p = 0.01; 4th, R = -0.30, P = 0.03; 5th, R = -0.31, p = 0.03; respectively). Only Ai from the fifth generation significantly correlated with FEV1%P in this lobe (R = 0.34, p = 0.01). LAA% strongly correlated with FEV1%P (R = -0.71, p < 0.001). We conclude therefore that quantitative airway measurements are significantly correlated with airflow limitation in AATD, particularly in the distal air-ways of RUL. Emphysema of the lower lung is the predominant component; however, airway disease also has a significant impact on airflow limitation in AATD.
dc.description.funderNIH
dc.description.funderParker a Francis Foundation
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/15412550903341521
dc.identifier.eissn1541-2563
dc.identifier.issn1541-2555
dc.identifier.pubmedidMEDLINE:19938971
dc.identifier.urihttps://doi.org/10.3109/15412550903341521
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76333
dc.identifier.wosidWOS:000273700800009
dc.information.autorucMedicina;Díaz A;S/I;104496
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final477
dc.pagina.inicio468
dc.publisherTAYLOR & FRANCIS INC
dc.revistaCOPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
dc.rightsacceso restringido
dc.subjectalpha(1) = antittypsin deficiency
dc.subjectChronic obstructive pulmonary disease
dc.subjectComputed topography
dc.subjectPulmonary emphysema
dc.subjectSmall airway disease
dc.subjectOBSTRUCTIVE PULMONARY-DISEASE
dc.subjectALPHA-1-ANTITRYPSIN DEFICIENCY
dc.subjectFLOW LIMITATION
dc.subjectHEALTH-STATUS
dc.subjectLUNG-FUNCTION
dc.subjectEMPHYSEMA
dc.subjectCT
dc.subjectBRONCHIECTASIS
dc.subjectDIMENSIONS
dc.subjectDENSITOMETRY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuantitative Airway Assessment on Computed Tomography in Patients with alpha(1)-antitrypsin Deficiency
dc.typeartículo
dc.volumen6
sipa.codpersvinculados104496
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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