Understanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development

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dc.article.number59
dc.catalogadoraba
dc.contributor.authorFelipe R. Uribe
dc.contributor.authorValentina P. I. González
dc.contributor.authorAlexis Kalergis
dc.contributor.authorJorge A. Soto
dc.contributor.authorKaren Bohmwald
dc.date.accessioned2024-03-04T15:19:42Z
dc.date.available2024-03-04T15:19:42Z
dc.date.issued2024
dc.description.abstractCentral nervous system (CNS) pathologies are a public health concern, with viral infections one of their principal causes. These viruses are known as neurotropic pathogens, characterized by their ability to infiltrate the CNS and thus interact with various cell populations, inducing several diseases. The immune response elicited by neurotropic viruses in the CNS is commanded mainly by microglia, which, together with other local cells, can secrete inflammatory cytokines to fight the infection. The most relevant neurotropic viruses are adenovirus (AdV), cytomegalovirus (CMV), enterovirus (EV), Epstein–Barr Virus (EBV), herpes simplex virus type 1 (HSV-1), and herpes simplex virus type 2 (HSV-2), lymphocytic choriomeningitis virus (LCMV), and the newly discovered SARS-CoV-2. Several studies have associated a viral infection with systemic lupus erythematosus (SLE) and neuropsychiatric lupus (NPSLE) manifestations. This article will review the knowledge about viral infections, CNS pathologies, and the immune response against them. Also, it allows us to understand the relevance of the different viral proteins in developing neuronal pathologies, SLE and NPSLE.
dc.fechaingreso.objetodigital2024-05-13
dc.format.extent30 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/brainsci14010059
dc.identifier.eissn2076-3425
dc.identifier.urihttps://doi.org/10.3390/brainsci14010059
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/82468
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final30
dc.pagina.inicio1
dc.revistaBrain Science
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNeurotropic viruses
dc.subjectCentral nervous system
dc.subjectAseptic meningitis
dc.subjectEncephalitis
dc.subjectImmune system
dc.subjectSystemic lupus erythematosus
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleUnderstanding the Neurotrophic Virus Mechanisms and Their Potential Effect on Systemic Lupus Erythematosus Development
dc.typeartículo
dc.volumen14
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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