Relation between body composition trajectories from childhood to adolescence and nonalcoholic fatty liver disease risk

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dc.article.number785
dc.catalogadorgjm
dc.contributor.authorAlberti, Gigliola
dc.contributor.authorFaune Palacios, Mariana Carmen
dc.contributor.authorSantos Martín, José Luis
dc.contributor.authorDe Barbieri Magnone, Florencia Beatriz
dc.contributor.authorGarcía B., Cristián
dc.contributor.authorPereira, Ana
dc.contributor.authorBecerra, Fernando
dc.contributor.authorGana Ansaldo, Juan Cristóbal
dc.date.accessioned2024-03-18T14:53:02Z
dc.date.available2024-03-18T14:53:02Z
dc.date.issued2024
dc.description.abstractNAFLD has become the leading cause of chronic liver disease in children, as a direct consequence of the high prevalence of childhood obesity. This study aimed to characterize body composition trajectories from childhood to adolescence and their association with the risk of developing nonalcoholic fatty liver disease (NAFLD) during adolescence. The participants were part of the ‘Chilean Growth and Obesity Cohort Study’, comprising 784 children who were followed prospectively from age 3 years. Annual assessments of nutritional status and body composition were conducted, with ultrasound screening for NAFLD during adolescence revealing a 9.8% prevalence. Higher waist circumference measures were associated with NAFLD from age 3 years (p = 0.03), all skin folds from age 4 years (p < 0.01), and DXA body fat measurements from age 12 years (p = 0.01). The fat-free mass index was higher in females (p = 0.006) but not in males (p = 0.211). The second and third tertiles of the fat mass index (FMI) had odds ratios for NAFLD during adolescence of 2.19 (1.48–3.25, 95% CI) and 6.94 (4.79–10.04, 95% CI), respectively. Elevated waist circumference, skin folds, and total body fat were identified as risk factors for future NAFLD development. A higher FMI during childhood was associated with an increased risk of NAFLD during adolescence.
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/nu16060785
dc.identifier.issn2072-6643
dc.identifier.urihttps://doi.org/10.3390/nu16060785
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84595
dc.information.autorucEscuela de Medicina; Alberti, Gigliola; 0000-0002-8540-1326; 167316
dc.information.autorucEscuela de Medicina; Faune Palacios, Mariana Carmen; S/I; 1015347
dc.information.autorucEscuela de Medicina; Santos Martín, José Luis; 0000-0003-2895-0369; 1005923
dc.information.autorucEscuela de Medicina; De Barbieri Magnone, Florencia Beatriz; S/I; 159736
dc.information.autorucEscuela de Medicina; García B., Cristián; S/I; 99686
dc.information.autorucEscuela de Medicina; Gana Ansaldo, Juan Cristóbal; 0000-0002-0400-2164; 8726
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaNutrients
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectLiver steatosis
dc.subjectBody composition
dc.subjectFat mass index
dc.subjectFat-free mass Index
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRelation between body composition trajectories from childhood to adolescence and nonalcoholic fatty liver disease risk
dc.typeartículo
dc.volumen16
sipa.codpersvinculados167316
sipa.codpersvinculados1015347
sipa.codpersvinculados1005923
sipa.codpersvinculados159736
sipa.codpersvinculados99686
sipa.codpersvinculados8726
sipa.trazabilidadORCID;2024-03-18
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