Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition

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dc.contributor.authorChang, Eric H.
dc.contributor.authorRigotti, Attilio
dc.contributor.authorHuerta, Patricio T.
dc.date.accessioned2024-01-10T12:37:28Z
dc.date.available2024-01-10T12:37:28Z
dc.date.issued2009
dc.description.abstractDysregulated cholesterol metabolism is a major risk factor for atherosclerosis and other late-onset disorders, such as Alzheimer's disease. The scavenger receptor, class B, type I (SR-BI) is critical in maintaining the homeostasis of cholesterol and alpha-tocopherol. SR-BI binds high-density lipoproteins (HDL) and mediates the selective transfer of cholesteryl esters and alpha-tocopherol from circulating HDL to cells. SR-BI is also involved in reverse cholesterol transport from peripheral tissues into the liver. Previous studies using SR-BI genetic knockout mice indicated that the deletion of SR-BI resulted in an accelerated onset of atherosclerosis. We hypothesized that SR-BI-dependent lipid dysregulation might disrupt brain function leading to cognitive impairment. Here, we report that very old SR-BI knockout mice show deficient synaptic plasticity (long-term potentiation) in the CA 1 region of the hippocampus. Very old SR-BI KO mice also display selective impairments in recognition memory and spatial memory. Thus, SR-BI influences neural and cognitive processes, a finding that highlights the contribution of cholesterol and alpha-tocopherol homeostasis in proper cognitive function. (C) 2007 Elsevier Inc. All rights reserved.
dc.description.funderBurke-Cornell Medical Research Institute
dc.description.funderNIH
dc.description.funderNYU
dc.description.funderAmerican Federation for Aging Research
dc.description.funderNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.neurobiolaging.2007.07.006
dc.identifier.eissn1558-1497
dc.identifier.issn0197-4580
dc.identifier.pubmedidMEDLINE:17719144
dc.identifier.urihttps://doi.org/10.1016/j.neurobiolaging.2007.07.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76853
dc.identifier.wosidWOS:000263154700007
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final419
dc.pagina.inicio407
dc.publisherELSEVIER SCIENCE INC
dc.revistaNEUROBIOLOGY OF AGING
dc.rightsacceso restringido
dc.subjectCholesterol
dc.subjectHDL
dc.subjectalpha-Tocopherol
dc.subjectScavenger receptors
dc.subjectLipid metabolism
dc.subjectAtherosclerosis
dc.subjectLate-onset Alzheimer's disease
dc.subjectLTP
dc.subjectRecognition memory
dc.subjectSpatial memory
dc.subjectHIGH-DENSITY-LIPOPROTEIN
dc.subjectLONG-TERM POTENTIATION
dc.subjectALPHA-TOCOPHEROL METABOLISM
dc.subjectCORONARY-ARTERY-DISEASE
dc.subjectALZHEIMERS-DISEASE
dc.subjectSCAVENGER RECEPTOR
dc.subjectAPOLIPOPROTEIN-E
dc.subjectNERVOUS-SYSTEM
dc.subjectDEFICIENT MICE
dc.subjectMOUSE MODEL
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAge-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition
dc.typeartículo
dc.volumen30
sipa.codpersvinculados68489
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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