11 beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients

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dc.contributor.authorMunoz, Rodrigo
dc.contributor.authorCarvajal, Cristian
dc.contributor.authorEscalona, Alex
dc.contributor.authorBoza, Camilo
dc.contributor.authorPerez, Gustavo
dc.contributor.authorIbanez, Luis
dc.contributor.authorFardella, Carlos
dc.date.accessioned2024-01-10T12:37:20Z
dc.date.available2024-01-10T12:37:20Z
dc.date.issued2009
dc.description.abstract11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) enzyme catalyzes interconversion of inactive cortisone to active cortisol. Its expression in adipose tissue has been associated with obesity and some of its metabolic disorders. Controversies regarding which fat depots [subcutaneous adipose tissue (SAT) or visceral adipose tissue (VAT)] have higher expression still remain. The aim of this work was to evaluate 11 beta-HSD1 expression in SAT and VAT of obese patients and evaluate its association to metabolic features of metabolic syndrome.
dc.description.abstractIn 32 morbidly obese patients, paired samples of SAT and VAT were collected. All patients, 40.2 +/- 12.3 years and 36.7 +/- 3.8 body mass index (BMI), underwent sleeve gastrectomy or laparoscopic gastric bypass. Gene expression of 11 beta-HSD1 in adipose tissue samples were determined by real-time reverse transcriptase polymerase chain reaction. Spearman correlation test was used to evaluate relationships between 11 beta-HSD1 levels and clinical and biochemical parameters.
dc.description.abstract11 beta-HSD1 mRNA levels were higher in SAT than in VAT, with median expression levels of 11.4 arbitrary units (AU) and 7.8 AU, respectively (p = 0.03). SAT 11 beta-HSD1 mRNA were correlated with VAT mRNA levels (r = -0.6, p = 0.018) and hip circumference (r = 0.66, p = 0.018). SAT 11 beta-HSD1 levels increase parallel according to BMI category. We did not find a correlation between SAT or VAT with fasting glucose (r = 0.15, p = NS), total cholesterol (r = 0.13, p = NS), triglycerides (r = 0.04, p = NS), and high-density lipoprotein (r = -0.16, p = NS). However, SAT expression in patients with features of MS was higher than those without features of MS.
dc.description.abstractOur results demonstrate that SATs express higher 11 beta-HSD1 mRNA levels than VAT. This finding highlights the importance of SAT in obesity and its possible role on metabolic disorders associated with obesity.
dc.description.funderFONDECYT
dc.description.funderMECESUP
dc.description.funderPontificia Universidad Catolica de Chile
dc.fechaingreso.objetodigital2024-03-14
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11695-008-9616-6
dc.identifier.eissn1708-0428
dc.identifier.issn0960-8923
dc.identifier.pubmedidMEDLINE:18592327
dc.identifier.urihttps://doi.org/10.1007/s11695-008-9616-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76822
dc.identifier.wosidWOS:000266262500013
dc.information.autorucMedicina;Boza C;S/I;761
dc.information.autorucMedicina;Carvajal C;S/I;8586
dc.information.autorucMedicina;Escalona A;S/I;94025
dc.information.autorucMedicina;Fardella C;S/I;66235
dc.information.autorucMedicina;Ibáñez L;S/I;99661
dc.information.autorucMedicina;Pérez G;S/I;5510
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final770
dc.pagina.inicio764
dc.publisherSPRINGER
dc.revistaOBESITY SURGERY
dc.rightsacceso restringido
dc.subjectAdipose tissue
dc.subject11 beta-Hydroxysteroid dehydrogenase type 1
dc.subjectMorbid obesity
dc.subjectGlucocorticoid
dc.subjectCortisol
dc.subjectCORONARY-HEART-DISEASE
dc.subjectBODY-FAT DISTRIBUTION
dc.subjectNECROSIS-FACTOR-ALPHA
dc.subjectDIABETES-MELLITUS
dc.subjectREGIONAL DIFFERENCES
dc.subjectPROVISIONAL REPORT
dc.subjectMETABOLIC-SYNDROME
dc.subjectLIPASE ACTIVITY
dc.subjectCELL SIZE
dc.subjectEXPRESSION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title11 beta-Hydroxysteroid Dehydrogenase Type 1 is Overexpressed in Subcutaneous Adipose Tissue of Morbidly Obese Patients
dc.typeartículo
dc.volumen19
sipa.codpersvinculados761
sipa.codpersvinculados8586
sipa.codpersvinculados94025
sipa.codpersvinculados66235
sipa.codpersvinculados99661
sipa.codpersvinculados5510
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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