Reducing household tuberculosis transmission. A pilot cluster-randomized controlled trial

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dc.contributor.authorRuiz-Tagle Seguel, Cinthya Grace
dc.contributor.authorSeguel Araus, Romina Javiera
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorBernales, Margarita
dc.contributor.authorVargas García, Salvador
dc.contributor.authorPizarro Ibañez, Alejandra Valentina
dc.contributor.authorPeña, Carlos
dc.contributor.authorNeira, Víctor
dc.contributor.authorGarcía Cañete, Patricia
dc.contributor.authorAllel Henríquez, Kasim Ignacio
dc.contributor.authorNathavitharana, Ruvandhi R.
dc.contributor.authorBalcells Marty, María Elvira
dc.date.accessioned2025-10-01T19:20:55Z
dc.date.available2025-10-01T19:20:55Z
dc.date.issued2025
dc.description.abstractBackground: The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce new tuberculosis infections in household contacts (HHCs). Methods: We conducted a pilot cluster-randomized controlled trial with a hybrid type 1 effectiveness-implementation design in Santiago, Chile. Random allocation was performed, and two healthcare districts were assigned to the intervention (n=180 HHCs) and one to standard of care (n=149 HHCs). Eligible participants were newly diagnosed pulmonary tuberculosis patients and their HHCs. The intervention included education, mask use, household ventilation, and nightly separation of tuberculosis patients, for two weeks. Intervention adherence was evaluated weekly. Effectiveness was assessed at the individual level with QuantiFERON®-TB Gold Plus (QFT) test conversions in HHCs at 12-week follow-up. Results: Between October 2021 and December 2023, 384 HHCs and 157 tuberculosis patients were enrolled. Overall, 56.3% of contacts were women, with mean age of 34.6 years and a baseline QFT positivity of 32.3%. A total of 216 contacts had negative QFT result at baseline, with 179 (82.9%) completing follow-up. QFT conversions occurred in 11 (12.8%) and 10 (10.8%) HHCs from the intervention and control arms, respectively (incidence risk ratio 1.10, 95% CI 0.71-1.71, p=0.849). Good adherence to the respiratory bundle was reported by 53% of participants on day 7 and 54% on day 14.
dc.fechaingreso.objetodigital2025-10-01
dc.format.extent18 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1093/cid/ciaf526
dc.identifier.eissn1537-6591
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105862
dc.identifier.urihttps://doi.org/10.1093/cid/ciaf526
dc.information.autorucEscuela de Medicina; Ruiz-Tagle Seguel, Cinthya Grace; S/I; 1098594
dc.information.autorucEscuela de Medicina; Seguel Araus, Romina Javiera; S/I; 234401
dc.information.autorucEscuela de Medicina; Villarroel del Pino, Luis A.; 0000-0001-9603-937X; 77182
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final18
dc.pagina.inicio1
dc.revistaClinical Infectious Diseases
dc.rightsacceso abierto
dc.subjectPulmonary tuberculosis
dc.subjectMycobacterium tuberculosis
dc.subjectHousehold contacts
dc.subjectPrevention
dc.subjectN95 respirators
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReducing household tuberculosis transmission. A pilot cluster-randomized controlled trial
dc.typeartículo
sipa.codpersvinculados1098594
sipa.codpersvinculados234401
sipa.codpersvinculados77182
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