Quantitative Assessment of Bronchial Wall Attenuation With Thin-Section CT: An Indicator of Airflow Limitation in Chronic Obstructive Pulmonary Disease

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dc.contributor.authorYamashiro, Tsuneo
dc.contributor.authorMatsuoka, Shin
dc.contributor.authorEstepar, Raul San Jose
dc.contributor.authorDransfield, Mark T.
dc.contributor.authorDiaz, Alejandro
dc.contributor.authorReilly, John J.
dc.contributor.authorPatz, Samuel
dc.contributor.authorMurayama, Sadayuki
dc.contributor.authorSilverman, Edwin K.
dc.contributor.authorHatabu, Hiroto
dc.contributor.authorWashko, George R.
dc.date.accessioned2024-01-10T13:16:54Z
dc.date.available2024-01-10T13:16:54Z
dc.date.issued2010
dc.description.abstractOBJECTIVE. The purpose of this study was to evaluate the relation between bronchial wall attenuation on thin-section CT images and airflow limitation in persons with chronic obstructive pulmonary disease. SUBJECTS AND
dc.description.abstractMETHODS. One hundred fourteen subjects (65 men, 49 women; age range, 56-74 years) enrolled in the National Lung Screening Trial underwent chest CT and prebronchodilation spirometry at a single institution. At CT, mean peak wall attenuation, wall area percentage, and luminal area were measured in the third, fourth, and fifth generations of the right B(1) and B(10) segmental bronchi. Correlations with forced expiratory volume in the first second of expiration (FEV(1)) expressed as percentage of predicted value were evaluated with Spearman's rank correlation test.
dc.description.abstractRESULTS. The peak wall attenuation of each generation of segmental bronchi correlated significantly with FEV(1) as percentage of predicted value (B(1) third, r = -0.323, p = 0.0005; B 1 fourth, r = -0.406, p < 0.0001; B(1) fifth, r = -0.478, p < 0.0001; B(10) third, r = -0.268, p = 0.004; B(10) fourth, r = -0.476, p < 0.0001; B(10) fifth, r = -0.548, p < 0.0001). The correlation coefficients were higher in peripheral airway generations. Wall area percentage and luminal area had similar significant correlations. In multivariate analysis to predict FEV(1) as percentage of predicted value, the coefficient of determination of the model with the combination of percentage of low-attenuation area (< -950 HU) and peak wall attenuation of the fifth generation of the right B(10) was 0.484; the coefficient of determination with percentage of low-attenuation area and wall area percentage was 0.40.
dc.description.abstractCONCLUSION. Peak attenuation of the bronchial wall measured at CT correlates significantly with expiratory airflow obstruction in subjects with chronic obstructive pulmonary disease, particularly in the distal airways.
dc.description.funderGlaxoSmithKline
dc.description.funderNIH
dc.description.funderParker B. Francis Foundation
dc.description.funderNATIONAL HEART, LUNG, AND BLOOD INSTITUTE
dc.fechaingreso.objetodigital2024-05-17
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.2214/AJR.09.3653
dc.identifier.issn0361-803X
dc.identifier.pubmedidMEDLINE:20651191
dc.identifier.urihttps://doi.org/10.2214/AJR.09.3653
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78622
dc.identifier.wosidWOS:000280197800012
dc.information.autorucMedicina;Díaz A;S/I;104496
dc.issue.numero2
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final369
dc.pagina.inicio363
dc.publisherAMER ROENTGEN RAY SOC
dc.revistaAMERICAN JOURNAL OF ROENTGENOLOGY
dc.rightsacceso restringido
dc.subjectairway wall attenuation
dc.subjectairway wall thickness
dc.subjectchronic obstructive pulmonary disease
dc.subjectCT
dc.subjectpulmonary emphysema
dc.subjectRESOLUTION COMPUTED-TOMOGRAPHY
dc.subjectDIMENSIONS
dc.subjectTHICKNESS
dc.subjectAIRWAYS
dc.subjectCOPD
dc.subjectEMPHYSEMA
dc.subjectACCURACY
dc.subjectDENSITY
dc.subjectSMOKERS
dc.subjectASTHMA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleQuantitative Assessment of Bronchial Wall Attenuation With Thin-Section CT: An Indicator of Airflow Limitation in Chronic Obstructive Pulmonary Disease
dc.typeartículo
dc.volumen195
sipa.codpersvinculados104496
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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