A(-6)G variant of angiotensinogen gene and aldosterone levels in hypertensives

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dc.article.number106217
dc.contributor.authorFardella, C
dc.contributor.authorZamorano, P
dc.contributor.authorMosso, L
dc.contributor.authorGomez, L
dc.contributor.authorPinto, M
dc.contributor.authorSoto, J
dc.contributor.authorOestreicher, E
dc.contributor.authorCortes, P
dc.contributor.authorClaverie, X
dc.contributor.authorMontero, J
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:22Z
dc.date.available2024-08-15T08:00:22Z
dc.date.issued1999
dc.description.abstractRecently, a novel mutation in the promoter region of the angiotensinogen gene that involves the presence of an adenine instead of a guanine 6 bp upstream from the transcription initiation site (A(-6)G) has been shown to induce an increase in gene transcription. The aim of this study was to determine the prevalence of the A(-6)G mutation in essential hypertensive patients and to correlate it with aldosterone and renin activity levels. We studied 191 hypertensives. We measured levels of aldosterone (plasma and urinary) and plasma renin activity. We determined the variants A and G using a mutagenically separated polymerase chain reaction technique. In 191 hypertensives, the A variant was detected in 266 of 382 (69.6%) and the G variant in 116 of 382 alleles (30.4%). Plasma aldosterone was significantly higher in patients homozygous for AA than in those homozygous for GG (369+/-208 versus 246+/-142 pmol/L). Urinary aldosterone was significantly higher in homozygous AA than in AG or GG patients (62.4+/-39.4 versus 50.8+/-25.2 and 37.4+/-22.3 nmol/d, respectively). When the patients were grouped according to the presence or absence of the A allele, the aldosterone levels and the plasma aldosterone/plasma renin activity ratio were significantly higher in patients with the A allele, The presence of the A variant was associated with higher levels of aldosterone. These results suggest that the presence of the A variant could determine the appearance of arterial hypertension through higher transcription activity of the angiotensinogen gene and concomitant aldosterone production.
dc.description.funderANID through FONDECYT
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/01.HYP.34.4.779
dc.identifier.eissn1524-4563
dc.identifier.issn0194-911X
dc.identifier.pubmedidMEDLINE:10523360
dc.identifier.scopusidSCOPUS_ID:0346985951
dc.identifier.urihttps://doi.org/10.1161/01.HYP.34.4.779
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87467
dc.identifier.wosidWOS:000083486500014
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero4
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final781
dc.pagina.inicio779
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaHYPERTENSION
dc.rightsregistro bibliográfico
dc.subjectangiotensinogen
dc.subjectaldosterone
dc.subjecthypertension
dc.subjectgenetics
dc.subjectrenin
dc.subjectCHILEAN POPULATION
dc.subjectRENIN-ACTIVITY
dc.subjectPROMOTER
dc.subjectPLASMA
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titleA(-6)G variant of angiotensinogen gene and aldosterone levels in hypertensives
dc.typeartículo
dc.volumen34
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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