Parsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study

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dc.catalogadoraba
dc.contributor.authorOliver, Dominic
dc.contributor.authorDavies, Cathy
dc.contributor.authorZelaya, Fernando
dc.contributor.authorSelvaggi, Pierluigi
dc.contributor.authorDe Micheli, Andrea
dc.contributor.authorCatalan, Ana
dc.contributor.authorBaldwin, Helen
dc.contributor.authorArribas, Maite
dc.contributor.authorModinos, Gemma
dc.contributor.authorCrossley, Nicolas A.
dc.contributor.authorAllen, Paul
dc.contributor.authorEgerton, Alice
dc.contributor.authorJauhar, Sameer
dc.contributor.authorHowes, Oliver D.
dc.contributor.authorMcGuire, Philip
dc.contributor.authorFusar-Poli, Paolo
dc.date.accessioned2024-06-10T21:25:34Z
dc.date.available2024-06-10T21:25:34Z
dc.date.issued2023
dc.description.abstractIntroductionThe impact of the clinical high-risk for psychosis (CHR-P) construct is dependent on accurately predicting outcomes. Individuals with brief limited intermittent psychotic symptoms (BLIPS) have higher risk of developing a first episode of psychosis (FEP) compared to individuals with attenuated psychotic symptoms (APS). Supplementing subgroup stratification with information from candidate biomarkers based on neurobiological parameters, such as resting-state, regional cerebral blood flow (rCBF), may help refine risk estimates. Based on previous evidence, we hypothesized that individuals with BLIPS would exhibit increased rCBF compared to APS in key regions linked to dopaminergic pathways. MethodsData from four studies were combined using ComBat (to account for between-study differences) to analyse rCBF in 150 age- and sex-matched subjects (n = 30 healthy controls [HCs], n = 80 APS, n = 20 BLIPS and n = 20 FEP). Global gray matter (GM) rCBF was examined in addition to region-of-interest (ROI) analyses in bilateral/left/right frontal cortex, hippocampus and striatum. Group differences were assessed using general linear models: (i) alone; (ii) with global GM rCBF as a covariate; (iii) with global GM rCBF and smoking status as covariates. Significance was set at p < 0.05. ResultsWhole-brain voxel-wise analyses and Bayesian ROI analyses were also conducted. No significant group differences were found in global [F(3,143) = 1,41, p = 0.24], bilateral frontal cortex [F(3,143) = 1.01, p = 0.39], hippocampus [F(3,143) = 0.63, p = 0.60] or striatum [F(3,143) = 0.52, p = 0.57] rCBF. Similar null findings were observed in lateralized ROIs (p > 0.05). All results were robust to addition of covariates (p > 0.05). No significant clusters were identified in whole-brain voxel-wise analyses (p > 0.05(FWE)). Weak-to-moderate evidence was found for an absence of rCBF differences between APS and BLIPS in Bayesian ROI analyses. ConclusionOn this evidence, APS and BLIPS are unlikely to be neurobiologically distinct. Due to this and the weak-to-moderate evidence for the null hypothesis, future research should investigate larger samples of APS and BLIPS through collaboration across large-scale international consortia.
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.fuente.origenORCID
dc.identifier.doi10.3389/fpsyt.2023.1092213
dc.identifier.issn1664-0640
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2023.1092213
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86723
dc.identifier.wosidWOS:000954257300001
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaFrontiers in psychiatry
dc.rightsacceso abierto
dc.rights.licenseATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectClinical high risk for psychosis
dc.subjectBrief limited intermittent psychotic symptoms
dc.subjectAttenuated psychosis syndrome
dc.subjectArterial spin labelling
dc.subjectNeuroimaging
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleParsing neurobiological heterogeneity of the clinical high-risk state for psychosis: A pseudo-continuous arterial spin labelling study
dc.typeartículo
dc.volumen14
sipa.trazabilidadORCID;2024-06-03
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