Manejo multidisciplinario y avances terapéuticos en la esclerosis lateral amiotrófica

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dc.catalogadorgrr
dc.contributor.authorMatamala, José Manuel
dc.contributor.authorMoreno-Roco, Javier
dc.contributor.authorAcosta, Ignacio
dc.contributor.authorHughes, RRicardo
dc.contributor.authorLillo, Patricia
dc.contributor.authorCasar Leturia, Juan Carlos
dc.contributor.authorEarle, Nicholas
dc.date.accessioned2024-01-10T13:45:27Z
dc.date.available2024-01-10T13:45:27Z
dc.date.issued2022
dc.description.abstractAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that mainly affects the motor system, resulting in progressive weakness and muscle wasting. Despite the tremendous advances in physiopathological and clinical characterization, we do not have a curative treatment yet. The progressive and fatal course of ALS makes its management particularly complex and challenging given the diversity of symptoms presenting during the disease progression. The main goal in the treatment of ALS patients is to minimize morbidity and maximize the quality of life. Currently, a series of therapeutic interventions improve the quality of life and prolong survival, including multidisciplinary care, respiratory management, and disease-modifying therapy. Within the supportive interventions, weight maintenance through nutritional and metabolic support is critical. In addition, the management of neuropsychiatric manifestations and preservation of communicative capacity before speech loss are also crucial. Lastly, early palliative care intervention is essential to optimize symptomatic management. Anticipatory guidelines to face the inevitable patient deterioration should be devised. This article updates the main therapeutic strategies used in these patients, including evolving clinical trials with promising novel therapies.
dc.fechaingreso.objetodigital2023-09-06
dc.fuente.origenScopus
dc.identifier.doi10.4067/S0034-98872022001201633
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.scieloid0034-98872022001201633
dc.identifier.scopusidSCOPUS_ID:85168579122
dc.identifier.urihttps://doi.org/10.4067/S0034-98872022001201633
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79036
dc.information.autorucEscuela de Medicina; Casar Leturia, Juan Carlos; S/I ; 1322
dc.issue.numero12
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1646
dc.pagina.inicio1633
dc.publisherSociedad Médica de Santiago
dc.revistaRevista Médica de Chile
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAmyotrophic Lateral Sclerosis
dc.subjectClinical Trial
dc.subjectPatient Care Team
dc.subjectQuality of Life
dc.subjectSurvival
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleManejo multidisciplinario y avances terapéuticos en la esclerosis lateral amiotrófica
dc.title.alternativeMultidisciplinary care and therapeutic advances in amyotrophic lateral sclerosisManejo multidisciplinario y avances terapéuticos en la esclerosis lateral amiotrófica
dc.typeartículo
dc.volumen150
sipa.codpersvinculados1322
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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