Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus

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dc.contributor.authorLindsay, Carolina B.
dc.contributor.authorZolezzi, Juan M.
dc.contributor.authorRivera, Daniela S.
dc.contributor.authorCisternas, Pedro
dc.contributor.authorBozinovic, Francisco
dc.contributor.authorInestrosa, Nibaldo C.
dc.date.accessioned2024-01-10T12:37:33Z
dc.date.available2024-01-10T12:37:33Z
dc.date.issued2020
dc.description.abstractAlzheimer's disease (AD) is a devastating neurodegenerative disorder in which superior brain functions, such as memory and cognition, are impaired. Currently, no effective treatment is available for AD. Although andrographolide (ANDRO), a compound extracted from the herb Andrographis paniculata, has shown interesting effects in models of several diseases, including AD, its effects on other molecular changes observed in AD, such as neuroinflammation and oxidative stress, have not yet been studied. To evaluate the impact of ANDRO-based intervention on the levels of amyloid-beta (A beta) and neuroinflammatory and oxidative stress markers in the brains of aged Octodon degus, a Chilean rodent, fifty-six-month-old O. degus were treated intraperitoneally with 2 or 4 mg/kg ANDRO. Vehicle-injected and 12-month-old O. degus were used as positive controls. Then, the protein levels of selected markers were assessed via immunohistochemistry and immunoblotting. ANDRO significantly reduced the total A beta burden as well as astrogliosis and interleukin-6 levels. Moreover, ANDRO significantly reduced the levels of 4-hydroxynonenal and N-tyrosine adducts, suggesting a relevant reduction in oxidative stress within aged O. degus brain. Considering that O. degus has been proposed as a potential "natural" model for sporadic AD due to the development of neuropathological markers that resemble this pathology, our results suggest that ANDRO should be further studied to establish its potential as a therapeutic drug for AD.
dc.description.funderFONDECYT
dc.description.funderBasal Center of Excellence in Science and Technology
dc.description.funderBasal Center of Excellence in Science and Technology (FONDECYT)
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12035-019-01784-6
dc.identifier.eissn1559-1182
dc.identifier.issn0893-7648
dc.identifier.pubmedidMEDLINE:31701436
dc.identifier.urihttps://doi.org/10.1007/s12035-019-01784-6
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76873
dc.identifier.wosidWOS:000495033800004
dc.information.autorucCiencias Biológicas;Bozinovic Kuscevic Francisco E;S/I;100031
dc.information.autorucCiencias Biológicas;Inestrosa Cantin Nibaldo Manue;S/I;99331
dc.information.autorucCiencias Biológicas;Rivera Rocabado Daniela Suzana;S/I;181471
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final1145
dc.pagina.inicio1131
dc.publisherSPRINGER
dc.revistaMOLECULAR NEUROBIOLOGY
dc.rightsacceso restringido
dc.subjectAndrographolide
dc.subjectAmyloid-beta
dc.subjectNeuroinflammation
dc.subjectOxidative stress
dc.subjectAlzheimer's disease
dc.subjectOctodon degus
dc.subjectAMYLOID-BETA-PEPTIDE
dc.subjectALZHEIMERS-DISEASE BRAIN
dc.subjectTOLL-LIKE RECEPTORS
dc.subjectNATURAL MODEL
dc.subjectLIPID-PEROXIDATION
dc.subjectPROTEIN
dc.subjectINFLAMMATION
dc.subjectACTIVATION
dc.subjectINHIBITION
dc.subjectFRIEND
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAndrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus
dc.typeartículo
dc.volumen57
sipa.codpersvinculados100031
sipa.codpersvinculados99331
sipa.codpersvinculados181471
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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