Early Obesity: Risk Factor for Fatty Liver Disease

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dc.contributor.authorCuzmar, Valeriau
dc.contributor.authorAlberti, Gigliola
dc.contributor.authorUauy, Ricardo
dc.contributor.authorPereira, Ana
dc.contributor.authorGarcia, Cristian
dc.contributor.authorDe Barbieri, Florencia
dc.contributor.authorCorvalan, Camila
dc.contributor.authorSantos, Jose L.
dc.contributor.authorMericq, Veronica
dc.contributor.authorVillarroel, Luis
dc.contributor.authorGana, Juan Cristobal
dc.date.accessioned2024-01-10T12:05:02Z
dc.date.available2024-01-10T12:05:02Z
dc.date.issued2020
dc.description.abstractNonalcoholic fatty liver disease (NAFLD), defined as fat accumulation greater than 5% in hepatocytes, may progress to fibrosis or cirrhosis later in life. NAFLD prevalence in adolescents has increased significantly in direct relation with obesity prevalence. Fatty liver has become the most frequent indication for liver transplantation in adults. Objective: The aim of the study was to identify anthropometric variables during the first 10 years of life associated to the risk of developing NAFLD in adolescence. Methods: Longitudinal cohort study 'Growth and Obesity Chilean Cohort Study' (GOCS) consisting of 513 children born in 2002 to 2003, with yearly anthropometric data collected over a 10-year period. The presence of intrahepatic fat in the livers of subjects 14 to 16 years of age was determined using abdominal ultrasound. In addition, elastography was performed on all participants with ultrasound evidence of NAFLD. Results: 9.7% of the participants presented findings compatible with NAFLD. After 2 years of age, obesity significantly and progressively increased the probability of NAFLD occurrence in adolescence. Obesity at 5 years of age was associated with the highest OR for NAFLD, reaching values of 8.91 (95% CI 3.03-16.11). Among participants with NAFLD, those with altered liver elasticity (>= 7 kPa) had greater weight, BMIz-score, waist and hip circumference, and altered liver enzymes (P < 0.05). Conclusion: The risk of developing NAFLD in adolescence increases progressively with early obesity starting at age 2 years.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.description.funder"Comision Nacional de Investigacion Cientifica y Tecnologica'' (CONICYT)
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/MPG.0000000000002523
dc.identifier.eissn1536-4801
dc.identifier.issn0277-2116
dc.identifier.pubmedidMEDLINE:31880680
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000002523
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75935
dc.identifier.wosidWOS:000561369900022
dc.information.autorucCiencias de la Salud;Cuzmar, Valeria;S/I;215768
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final98
dc.pagina.inicio93
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsacceso restringido
dc.subjectanthropometric risk factors
dc.subjectevolution of nutritional status
dc.subjectDIAGNOSIS
dc.subjectHEPATOLOGY
dc.subjectFIBROSIS
dc.subjectCHILDREN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEarly Obesity: Risk Factor for Fatty Liver Disease
dc.typeartículo
dc.volumen70
sipa.codpersvinculados215768
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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