Variability of Water Uptake Studies of Biomedical Polymers

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dc.contributor.authorValenzuela, Loreto M.
dc.contributor.authorMichniak, Bozena
dc.contributor.authorKohn, Joachim
dc.date.accessioned2024-01-10T13:44:10Z
dc.date.available2024-01-10T13:44:10Z
dc.date.issued2011
dc.description.abstractWater uptake influences many properties of polymers and has been widely studied. In the context of polymeric biomaterials, several publications reported an unusual high variability of analytical results, without further investigating the cause for this phenomenon. Using selected polymers from the library of L-tyrosine-derived polyarylates and poly(D,L lactic acid), we showed that nonaged and nonannealed compression molded film samples exhibit the typical large variation in water uptake observed in previous reports. The introduction of an annealing step allows accurate and reproducible water uptake measurements for these polymers. We evaluated the use of 3 H-radiolabeled water for the determination of water uptake, finding that the use of radiolabeled water yields statistically indistinguishable measurements, compared to gravimetric methods, while providing significant advantages in throughput and sensitivity. Using the recommended methods of annealing and (3)H-radiolabled water, the water uptake profiles of 24 polymers of the library of L-tyrosine-derived polyarylates are reported. This article addresses experimental concerns related to water uptake studies and may assist other researchers in improving the accuracy of their water uptake results. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 1311-1320, 2011
dc.description.funderNational Institutes of Health (NIBIB and NCMHD)
dc.description.funderRESBIO (Integrated Technology Resource for Polymeric Biomaterials), New Jersey Center for Biomaterials
dc.description.funderPontificia Universidad Catolica de Chile
dc.description.funderChilean government
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/app.33485
dc.identifier.issn0021-8995
dc.identifier.urihttps://doi.org/10.1002/app.33485
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78855
dc.identifier.wosidWOS:000291436600009
dc.information.autorucIngeniería;Valenzuela L;S/I;18207
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1320
dc.pagina.inicio1311
dc.publisherWILEY-BLACKWELL
dc.revistaJOURNAL OF APPLIED POLYMER SCIENCE
dc.rightsacceso restringido
dc.subjectwater absorption
dc.subjectdiffusion
dc.subjectannealing
dc.subjecthydrolytic degradation
dc.subjectpolyester
dc.subjectSTIMULATED DEPOLARIZATION CURRENTS
dc.subjectDRUG-RELEASE
dc.subjectHYDROLYTIC DEGRADATION
dc.subjectIN-VITRO
dc.subjectMECHANICAL-PROPERTIES
dc.subjectBLOOD COMPATIBILITY
dc.subjectPHYSICAL-PROPERTIES
dc.subjectDIFFUSION BEHAVIOR
dc.subjectTHERMAL-PROPERTIES
dc.subjectMOLECULAR-WEIGHT
dc.subject.ods12 Responsible Consumption and Production
dc.subject.odspa12 Producción y consumo responsable
dc.titleVariability of Water Uptake Studies of Biomedical Polymers
dc.typeartículo
dc.volumen121
sipa.codpersvinculados18207
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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