A simple method to assess estrogen receptor gene (ESR1) amplification in paired biopsies from primary tumor and recurrence in breast cancer patients receiving endocrine therapy

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dc.catalogadorpva
dc.contributor.authorMaiz, Cristóbal
dc.contributor.authorOddó, David
dc.contributor.authorAlfaro, Francisca
dc.contributor.authorVillarroel, Alejandra
dc.contributor.authorAcevedo, Francisco
dc.contributor.authorPérez Sepulveda, Alejandra
dc.contributor.authorMuñiz, Sabrina
dc.contributor.authorSilva, Fernando
dc.contributor.authorValdivia, Andrés
dc.contributor.authorMerino, Tomas
dc.contributor.authorPinto, Mauricio P.
dc.contributor.authorSánchez, César
dc.date.accessioned2024-01-19T18:21:50Z
dc.date.available2024-01-19T18:21:50Z
dc.date.issued2020
dc.description.abstractGlobally, Breast Cancer (BC) is the leading cause of cancer death among women. About 75% of patients are diagnosed with hormone-dependent tumors and are set to receive Endocrine Therapy (ET) targeting the estrogen receptor. Unfortunately, a significant proportion of these patients develops ET resistance. Still controversial, studies have proposed that Estrogen Receptor-Alpha Gene (ESR1) alterations may underlie ET resistance. Here, we describe the use of a Chromogenic in Situ Hybridization (CISH) assay for the assessment of ESR1 amplification in primary tumors and recurrences. This assay could be a useful clinical tool with therapeutic implications for estrogen receptor positive BC patients.
dc.fechaingreso.objetodigital2024-05-15
dc.fuente.origenORCID-ene24
dc.identifier.doi10.26717/bjstr.2020.25.004188
dc.identifier.issn2574 -1241
dc.identifier.urihttp://dx.doi.org/10.26717/bjstr.2020.25.004188
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80809
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final19079
dc.pagina.inicio19076
dc.revistaBiomedical Journal of Scientific & Technical Research
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution 4.0 International Licens
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectESR1
dc.subjectBreast cancer
dc.subjectEstrogen-receptor amplification
dc.subjectEndocrine therapy
dc.subjectEndocrine therapy resistance
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleA simple method to assess estrogen receptor gene (ESR1) amplification in paired biopsies from primary tumor and recurrence in breast cancer patients receiving endocrine therapy
dc.typeartículo
dc.volumen25
sipa.codpersvinculados119540
sipa.trazabilidadORCID;2024-01-08
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