25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemias

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dc.article.numbere20210004
dc.catalogadorgjm
dc.contributor.authorLeiva, Carla
dc.contributor.authorBravo Jiménez, Paulina
dc.contributor.authorArias, Carolina
dc.contributor.authorCabello, Juan
dc.contributor.authorLeal-Witt, María Jesús
dc.contributor.authorSalazar Silva, Florencia
dc.contributor.authorCornejo, Verónica
dc.date.accessioned2023-05-19T20:45:31Z
dc.date.available2023-05-19T20:45:31Z
dc.date.issued2021
dc.description.abstractIt has been shown that there is a decrease in the concentrations of 25 hydroxyvitamin D (25-OHD) and bone mineral density (BMD) in patients with phenylketonuria (PKU) in their follow-up. Our objective was to determine concentrations of 25-OHD in subjects with PKU and hyperphenylalaninemia (HPA). Transversal analytical study considered three groups: G1-PKU with neonatal diagnosis and formula intake without Phe; G2-HPA, without specific treatment and G3-C control group. Sixteen patients per group (aged 6-23) were included. Levels of 25-OHD, lumbar spine (L2-L4), femur and total BMD, intact parathormone (PTH) and vitamin D (VitD) and calcium intake were calculated. The Kruskal-Wallis statistical test was applied (p-value<0,05). Significant differences were detected in concentrations of 25-OHD between G1-PKU and G2-HPA (38.9 ng/mL; 28 ng/mL, respectively) (NV: >30 ng/mL). G1-PKU had a higher intake of VitD, with differences among groups. There were no significant differences among groups in relation to BMD and intact PTH. In conclusion, G1-PKU under treatment and with good adherence, does not present VitD deficiency and no BMD alterations are observed. In contrast, G2-HPA had a lower intake of VitD and decreased 25-OHD concentrations which could affect the bone architecture in the long term. Further studies on the G2-HPA are suggested.
dc.fechaingreso.objetodigital2023-07-14
dc.format.extent10 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1590/2326-4594-jiems-2021-0004
dc.identifier.eissn2326-4594
dc.identifier.urihttps://doi.org/10.1590/2326-4594-JIEMS-2021-0004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/69491
dc.information.autorucEscuela de Medicina; Leiva, Carla; 0000-0001-7193-8133; 1023977
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaJournal of Inborn Errors of Metabolism and Screening
dc.rightsacceso abierto
dc.subjectPhenylketonuriaes_ES
dc.subjectVitamin D and bone mineral densityes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.title25 Hydroxy Vitamin D Level, Bone Health, Vitamin D and Calcium Intake in Chilean Patients with Phenylketonuria and Hyperphenylalaninemiases_ES
dc.typeartículo
dc.volumen9
sipa.codpersvinculados1023977
sipa.indexScielo
sipa.trazabilidadORCID;14-07-2023
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