An elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome

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dc.contributor.authorVaisbuch, Edi
dc.contributor.authorRomero, Roberto
dc.contributor.authorGomez, Ricardo
dc.contributor.authorKusanovic, Juan Pedro
dc.contributor.authorMazaki Tovi, Shali
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorHassan, Sonia S.
dc.date.accessioned2024-01-10T13:45:47Z
dc.date.available2024-01-10T13:45:47Z
dc.date.issued2011
dc.description.abstractMethods. aEuro integral Fetal blood sampling was performed in sensitized Rh-D negative women with suspected fetal anemia (n aEuroS== aEuroS16). Fetal anemia was diagnosed according to reference range nomograms established for the assessment of fetal hematologic parameters. An elevated fetal plasma IL-6 concentration was defined using a cutoff of > 11 pg/ml. Concentrations of IL-6 were determined by immunoassay. Non-parametric statistics were used for analysis.
dc.description.abstractResults. aEuro integral(1) The prevalence of an elevated fetal plasma IL-6 was 25%% (4/16); (2) there was an inverse relationship between the fetal hematocrit and IL-6 concentration -- the lower the hematocrit, the higher the fetal IL-6 (r aEuroS== aEuroS--0.68, p aEuroS== aEuroS0.004); (3) fetuses with anemia had a significantly higher plasma IL-6 concentration than those without anemia (3.74 pg/ml, interquartile range (IQR) 1.18--2.63 vs. 1.46 pg/ml, IQR 1.76--14.7; p aEuroS== aEuroS0.02); (4) interestingly, all fetuses with an elevated plasma IL-6 concentration had anemia (prevalence 40%%, 4/10), while in the group without anemia, none had an elevated fetal plasma IL-6.
dc.description.abstractConclusions. aEuro integral An elevation in fetal plasma IL-6 can be observed in a subset of fetuses with anemia due to Rh alloimmunization. This observation suggests that the hallmark of FIRS can be caused by non-infection-related insults. Further studies are required to determine whether the prognosis of FIRS caused by intra-amniotic infection/inflammation is different from that induced by alloimmunization.
dc.description.funderPerinatology Research Branch
dc.description.funderDivision of Intramural Research
dc.description.funderEunice Kennedy Shriver National Institute of Child Health
dc.description.funderHuman Development, NIH, DHHS
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3109/14767058.2010.507294
dc.identifier.eissn1476-4954
dc.identifier.issn1476-7058
dc.identifier.pubmedidMEDLINE:20701435
dc.identifier.urihttps://doi.org/10.3109/14767058.2010.507294
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79080
dc.identifier.wosidWOS:000286993000001
dc.information.autorucMedicina;Gomez R ;S/I;80926
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final396
dc.pagina.inicio391
dc.publisherTAYLOR & FRANCIS LTD
dc.revistaJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.rightsacceso restringido
dc.subjectFetal anemia
dc.subjectFIRS
dc.subjectinterleukin-6
dc.subjectpregnancy
dc.subjectRh hemolytic disease
dc.subjectPRETERM PREMATURE RUPTURE
dc.subjectUMBILICAL-CORD PLASMA
dc.subjectINTRAAMNIOTIC INFLAMMATION
dc.subjectRHESUS ALLOIMMUNIZATION
dc.subjectTHYMIC INVOLUTION
dc.subjectCEREBRAL-PALSY
dc.subjectCHORIOAMNIONITIS
dc.subjectMANAGEMENT
dc.subjectASSOCIATION
dc.subjectACTIVATION
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleAn elevated fetal interleukin-6 concentration can be observed in fetuses with anemia due to Rh alloimmunization: implications for the understanding of the fetal inflammatory response syndrome
dc.typeartículo
dc.volumen24
sipa.codpersvinculados80926
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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