Metabolic syndrome and subclinical atherosclerosis in children

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dc.article.number1
dc.catalogadorpau
dc.contributor.authorArnáiz Gómez, Pilar
dc.contributor.authorVillarroel del Pino, Luis A.
dc.contributor.authorGodoy J., Iván
dc.contributor.authorBarja Y., Salesa
dc.contributor.authorCastillo Valenzuela, Oscar
dc.contributor.authorFarías Jofré, Marcelo Enrique
dc.contributor.authorDomínguez de Landa, María Angélica
dc.contributor.authorMardones S., Francisco
dc.date.accessioned2023-07-10T20:37:49Z
dc.date.available2023-07-10T20:37:49Z
dc.date.issued2011
dc.description.abstractAtherosclerosis begins in childhood in response to the clustering of metabolic syndrome (MS) risk components since early life. Carotid intima-media thickness (CIMT), a surrogate marker of subclinical atherosclerosis, has been strongly related with cardiovascular disease and Diabetes 2 in adulthood. We aimed to study the possible association of CIMT with the MS components in a population of Chilean children. A cross-sectional study of 304 children of low socio-economic strata from an urban area of Santiago was performed during 2009-2010. This sample was selected mainly considering the presence of one or more MS components and insulin resistance (IR). Anthropometry and systolic and diastolic blood pressure were assessed by trained personnel. While fasting, a blood sample was taken to determine lipids (enzymatic colorimetric tests), glycemia (hexoquinase), insulin (quimioluminiscence) and HOMA. CIMT was assessed using ultrasonography with automated software. Pearson correlation, chi-squared test and stepwise regression were used. Mean age was 11.5 ± 0.9 years old; 57% girls and 42% pre-pubertal; 64% overweight; and 25% had MS. MS components distribution was: 20% had 0, 29% had one, 26% had two and 25% had three or more. Pearson coefficients for CIMT medium and maximum with systolic blood pressure were: 0.206 (p 0.0003) and r: 0.213 (p 0.0002). Some MS components and IR had higher proportions of children over the 75th percentile of CIMT medium and maximum in the contingency tables: 1) the proportion of children with high CIMT medium was significantly higher for IR (0.035) and CHDL ≤ 40 mg/dL (p 0.039); 2) A tendency for significant differences was found for the proportions of children with high (>75th percentile) CIMT medium with waist circumference (p 0.052) and children with high (>75th percentile) CIMT maximum with CHDL ≤ 40 mg/dL (p 0.062). Multiple linear regression models for CIMT medium and maximum selected just systolic blood pressure in both; p values were 0.0003 and 0.0002. Univariate analyses showed that CIMT medium and maximum were directly associated with systolic blood pressure. Bivariate analyses showed that CIMT medium was significantly associated with IR and CHDL ≤ 40 mg/dL. However, multiple regression models for both CIMTs just selected systolic blood pressure, a fact that would make it a proxy for CIMTs. These results are the first reported in our country.
dc.fechaingreso.objetodigital2023-07-10
dc.format.extent1 página
dc.fuente.origenORCID
dc.identifier.doi10.1017/S2040174411000481
dc.identifier.issn2040-1744
dc.identifier.urihttps://publons.com/wos-op/publon/18675503/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74155
dc.information.autorucEscuela de Medicina ; Arnáiz Gómez, Pilar ; S/I ; 98982
dc.information.autorucEscuela de Medicina ; Villarroel del Pino, Luis A. ; 0000-0001-9603-937X ; 77182
dc.information.autorucEscuela de Medicina ; Godoy J., Iván ; S/I ; 70048
dc.information.autorucEscuela de Medicina ; Barja Y., Salesa ; 0000-0001-8583-188X ; 64532
dc.information.autorucEscuela de Medicina ; Castillo Valenzuela, Oscar ; 0000-0002-4411-8655 ; 1000391
dc.information.autorucEscuela de Medicina ; Farías Jofré, Marcelo Enrique ; 0000-0003-0473-2295 ; 12286
dc.information.autorucEscuela de Medicina ; Domínguez de Landa, María Angélica ; 0000-0001-7477-7574 ; 131798
dc.information.autorucEscuela de Medicina ; Mardones S., Francisco ; 0000-0002-0905-9493 ; 98805
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.finalS72
dc.pagina.inicioS72
dc.relation.ispartofWorld Congress on Developmental Origins of Health and Disease (7° ; 2011 ; Portland, United States of America)
dc.revistaJournal of Developmental Origins of Health and Disease
dc.rightsacceso restringido
dc.titleMetabolic syndrome and subclinical atherosclerosis in childrenes_ES
dc.typecomunicación de congreso
dc.volumen2
sipa.codpersvinculados98982
sipa.codpersvinculados77182
sipa.codpersvinculados70048
sipa.codpersvinculados64532
sipa.codpersvinculados1000391
sipa.codpersvinculados12286
sipa.codpersvinculados131798
sipa.codpersvinculados98805
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