Relationship of Multifocal Electroretinographic Responses and Macular Layer Volume in Eyes Treated for Retinopathy of Prematurity

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dc.contributor.authorAlWattar, Bilal K.
dc.contributor.authorPatel, Jagvi K.
dc.contributor.authorFonseca, Mariana I.
dc.contributor.authorNouck-A-Nwal, Alexandra
dc.contributor.authorAltschwager, Pablo
dc.contributor.authorFulton, Anne B.
dc.contributor.authorAkula, James D.
dc.date.accessioned2024-01-10T14:24:18Z
dc.date.available2024-01-10T14:24:18Z
dc.date.issued2022
dc.description.abstractPurpose: To determine the association of the multifocal electroretinographic (mfERG) response amplitude with the volumes of the inner, postreceptor, and photoreceptor retinal layers in the region stimulated by each mfERG element.Methods: Sixteen healthy, young adult control subjects were studied. Each of the 103 hexagonal elements of the standard, scaled mfERG were aligned, where possible, with patches of retina imaged using optical coherence tomography. Stimuli falling on the fovea and on the optic nerve head were excluded. Linear mixed-effects modeling was then used to derive estimated coefficients (voltage/volume) for the mfERG response throughout the full 80 ms standard epoch. The resulting predicted response amplitudes originating in each layer were then compared to pharmacologically "dissected" mfERGs obtained from other studies in monkey eyes.Results: Across the duration of the response, the amplitude of the modeled contribution from (1) the inner retina was small-to-modest, (2) the postreceptor retina was larger and contained two prominent peaks, and (3) the photoreceptor response was the largest and most closely paralleled the overall (i.e., intact) response, including late-appearing oscillations. The significance of each layer's contribution was greatest when the absolute amplitude of that layer's response was largest. The contribution of the inner retina was maximally significant in the interval between the prominent troughs and peaks of the intact response. The contributions of the postreceptor and photoreceptor responses were maximally significant at the prominent troughs and peaks of the intact response.Conclusions: The results of the model were in good overall agreement with previous interpretations of the cellular contributions to the mfERG. There was also fair agreement with pharmacologically dissected monkey mfERG responses. Thus, the estimations of the contributions of the retinal layers to the mfERG so produced appeared plausible.
dc.description.funderNIH
dc.fechaingreso.objetodigital2024-05-15
dc.fuente.origenWOS
dc.identifier.eissn1552-5783
dc.identifier.issn0146-0404
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80210
dc.identifier.wosidWOS:000844437005275
dc.information.autorucEscuela de Medicina; Altschwager Kreft Pablo Andres; 0000-0002-0354-4295; 12598
dc.issue.numero7
dc.language.isoen
dc.nota.accesoSin adjunto
dc.publisherASSOC RESEARCH VISION OPHTHALMOLOGY INC
dc.revistaINVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
dc.rightsregistro bibliográfico
dc.subjectMultifocal electroretinogram
dc.subjectOCT
dc.subjectOptical coherence tomography
dc.subjectmfERG
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRelationship of Multifocal Electroretinographic Responses and Macular Layer Volume in Eyes Treated for Retinopathy of Prematurity
dc.typecomunicación de congreso
dc.volumen63
sipa.codpersvinculados12598
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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