Performance evaluation of paediatric propofol pharmacokinetic models in healthy young children

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dc.contributor.authorSepulveda, P.
dc.contributor.authorCortinez, L. I.
dc.contributor.authorSaez, C.
dc.contributor.authorPenna, A.
dc.contributor.authorSolari, S.
dc.contributor.authorGuerra, I.
dc.contributor.authorAbsalom, A. R.
dc.date.accessioned2024-01-10T13:51:58Z
dc.date.available2024-01-10T13:51:58Z
dc.date.issued2011
dc.description.abstractBackground. The performance of eight currently available paediatric propofol pharmacokinetic models in target-controlled infusions (TCIs) was assessed, in healthy children from 3 to 26 months of age.
dc.description.abstractMethods. Forty-one, ASA I-II children, aged 3-26 months were studied. After the induction of general anaesthesia with sevoflurane and remifentanil, a propofol bolus dose of 2.5 mg kg 21 followed by an infusion of 8 mg kg 21 h 21 was given. Arterial blood samples were collected at 1, 2, 3, 5, 10, 20, 40, and 60 min post-bolus, at the end of surgery, and at 1, 3, 5, 30, 60, and 120 min after stopping the infusion. Model performance was visually inspected with measured/predicted plots. Median performance error (MDPE) and the median absolute performance error (MDAPE) were calculated to measure bias and accuracy of each model.
dc.description.abstractResults. Performance of the eight models tested differed markedly during the different stages of propofol administration. Most models underestimated propofol concentration 1 min after the bolus dose, suggesting an overestimation of the initial volume of distribution. Six of the eight models tested were within the accepted limits of performance (MDPE<20% and MDAPE<30%). The model derived by Short and colleagues performed best.
dc.description.abstractConclusions. Our results suggest that six of the eight models tested perform well in young children. Since most models overestimate the initial volume of distribution, the use for TCI might result in the administration of larger bolus doses than necessary.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1093/bja/aer198
dc.identifier.issn0007-0912
dc.identifier.pubmedidMEDLINE:21743068
dc.identifier.urihttps://doi.org/10.1093/bja/aer198
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79636
dc.identifier.wosidWOS:000294807400017
dc.information.autorucMedicina;Cortinez L;S/I;79356
dc.information.autorucMedicina;Guerra I ;S/I;117495
dc.information.autorucMedicina;Solari S ;S/I;1871
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final600
dc.pagina.inicio593
dc.publisherOXFORD UNIV PRESS
dc.revistaBRITISH JOURNAL OF ANAESTHESIA
dc.rightsacceso restringido
dc.subjectanaesthetics i.v., propofol
dc.subjectchildren
dc.subjectdrug infusion systems
dc.subjectpharmacokinetics
dc.subjectCOMPUTER-CONTROLLED INFUSION
dc.subjectBISPECTRAL INDEX
dc.subjectINTRAVENOUS BOLUS
dc.subjectANESTHESIA
dc.subjectBLOOD
dc.subjectPARAMETERS
dc.subjectPAEDFUSOR
dc.subjectKINETICS
dc.subjectINFANTS
dc.subjectSURGERY
dc.titlePerformance evaluation of paediatric propofol pharmacokinetic models in healthy young children
dc.typeartículo
dc.volumen107
sipa.codpersvinculados79356
sipa.codpersvinculados117495
sipa.codpersvinculados1871
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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